INT J MOL SCI, 23, 7, 3462, 1-19 (2022)

6 dubna, 2022 9:52 am Published by Leave your thoughts

IF 5,924 

Laccases and Tyrosinases in Organic Synthesis

Ludmila Martínková, Barbora Křístková, Vladimír Křen 


Laccases (Lac) and tyrosinases (TYR) are mild oxidants with a great potential in research and industry. In this work, we review recent advances in their use in organic synthesis. We summarize recent examples of Lac‐catalyzed oxidation, homocoupling and heterocoupling, and TYR‐catalyzed ortho‐hydroxylation of phenols. We highlight the combination of Lac and TYR with other enzymes or chemical catalysts. We also point out the biological and pharmaceutical potential of the products, such as dimers of piceid, lignols, isorhamnetin, rutin, caffeic acid, 4‐hydroxychalcones, thiols, hybrid antibiotics, benzimidazoles, benzothiazoles, pyrimidine derivatives, hydroxytyrosols, alkylcatechols, halocatechols, or dihydrocaffeoyl esters, etc. These products include radical scavengers; antibacterial, antiviral, and antitumor compounds; and building blocks for bioactive compounds and drugs. We summarize the available enzyme sources and discuss the scalability of their use in organic synthesis. In conclusion, we assume that the intensive use of laccases and tyrosinases in organic synthesis will yield new bioactive compounds and, in the long‐term, reduce the environmental impact of industrial organic chemistry.

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