Our laboratory takes part in research project funded under Europien Commission.
- Novel Biocatalysts for the Production of Glycosides
- Research area: KBBE.2010.3.3–01 Robust and novel biocatalysts for industrial
applications - Call: FP7-KBBE-2010–4
More information sources:
Novosides is a collaborative research project funded by the European Commission under the Seventh
Framework Programme (FP7). Four academic institutes and two industrial partners from five European
countries are involved in the work packages.
Our goal is the such as flavonoids, alkaloids and steroids. Glycosylation can drastically improve
both the physicochemical and biological properties of these molecules, but very few
biocatalysts are currently available to perform this modification cost-efficiently at the industrial
scale.
The glycosylation potential of will now be explored in more detail. These enzymes catalyze the
transfer a glycosyl group from cheap and readily available donor substrates (e.g. sucrose) to
different acceptor molecules.
To maximize their performance, the enzymes’ by means of directed evolution, using novel
fluorescent probes as tools for high-throughput screening. The reactions will then be optimised and
scaled-up at pilot plant facilities to allow the commercial exploitation of the
glycosylated products.
Staff directly involved
- Ing. Eva Vavříková, PhD.
- Ing. Petr Šimon
Doc. Ing. Kateřina Valentová, PhD.