Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

ACS Omega, 9, 32, 34938-34950 (2024)

IF 3,7 Nitrogen-Containing Flavonoids–Preparation and Biological Activity Martina Hurtová, Daniela Brdová, Bára Křížskovská, Guglielmo Tedeschi, Tomáš Nejedlý, Ondřej Strnad, Simona...
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ChemCatChem, 16, 11, e202400028: 1-7 (2024)

IF 3,8 Expanding Rutinosidase Versatility: Acylated Quercetin Glucopyranosides as Substrates Katerina Brodsky, Lucie Petrásková, Michal Kutý, Pavla Bojarová, Helena Pelantová,...
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Journal of Agricultural and Food Chemistry, 72, 28, 15613-15623 (2024)

IF 5,7 Three-Step Enzymatic Remodeling of Chitin into Bioactive Chitooligomers Zuzana Mészáros, Natalia Kulik, Lucie Petrásková, Pavla Bojarová, Mònica Texidó,...
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Journal of Medicinal Chemistry, 67, 11, 9214-9226 (2024)

IF 6,8 Glycopolymer Inhibitors of Galectin-3 Suppress the Markers of Tissue Remodeling in Pulmonary Hypertension Antonín Sedlář, David Vrbata, Kateřina...
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Process Biochemistry, 142, 62-67 (2024)

IF 3,7 Biotransformation of free cyanide to formic acid by a cyanide hydratase-formamidase cascade reaction Ludmila Martínková, Natalia Kulik, Lenka...
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Bioorganic Chemistry, 148, 107452:1-12 (2024)

IF 4,5 Diaminocyclopentane – L-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase Patrick Weber, Pavla Bojarová, Jitka Brouzdová, Vladimír...
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Bioorganic Chemistry, 147, 107395:1-12 (2024)

IF 4,5 Synthesis and unexpected binding of monofluorinated N, N‘-diacetylchitobiose and LacdiNAc to wheat germ agglutinin Martin Kurfiřt, Vojtěch Hamala,...
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