Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

Journal of Agricultural and Food Chemistry 68, 40, 11197-11206 (2020)

IF 4,192 Sulfated Metabolites of Luteolin, Myricetin, and Ampelopsin: Chemoenzymatic Preparation and Biophysical Properties Kristýna Káňová, Lucie Petrásková, Helena Pelantová,...
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Advanced Synthesis & Catalysis, 362, 19, 4138-4150 (2020)

IF 5,851 How Site-Directed Mutagenesis Boosted Selectivity of a Promiscuous Enzyme Pavlína Nekvasilová, Natalia Kulik, Nikola Rychlá, Helena Pelantová, Lucie...
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ANTIOXIDANTS & REDOX SIGNALING, 33, 12, 789-815 (2020)

IF 6,323 Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD+...
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Chemistry-A European Journal 26, 43, 9620-9631 (2020)

IF 4,857 Regioselective 3-O-Substitution of Unprotected Thiodigalactosides: Direct Route to Galectin Inhibitors  Tomáš Vašíček, Vojtěch Spiwok, Jakub Červený, Lucie Petrásková,...
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BioMACROMOLECULES 21, 8, 3122-3133 (2020)

IF 6,092 Glycopolymers for Efficient Inhibition of Galectin-3: In Vitro Proof of Efficacy Using Suppression of T Lymphocyte Apoptosis and...
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BioTech 2020-2021

June 16-19,2021 Prague BioTech 2020 and 8th Czech-Swiss Symposium with exhibition will cover all important aspects of advanced biotechnologies. The...
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