Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

ChemComm 58, 63, 8838-8841 (2022)

IF 6,065 Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer’s disease Weber Patrick, Mészáros Zuzana, Jagečić Denis, Hribljan Valentina, Mitrečić Dinko, Bojarová Pavla, ...
Read More

Bioorganic Chemistry, 127, 105983, 1-13 (2022)

IF 5,307 Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura...
Read More

Natural Product Reports, 39, 6, 1264-1281 (2022)

IF 13,423 Silybin and its congeners: from traditional medicine to molecular effects Vladimír Křen, Kateřina Valentová  Abstract Silymarin, an extract...
Read More

Advanced Synthesis & Catalysis,364, 12, 2009-2022 (2022)

IF 5,837 Hypertransglycosylating Variants of the GH20 β-N-Acetylhexosaminidase for the Synthesis of Chitooligomers Zuzana Mészáros, Lucie Petrásková, Natalia Kulik, Helena...
Read More

J. Photochem. Photobiol. A-Chem. 429, 113897, 1-12 (2022)

IF 4,291 Stability and ultraviolet A photostability of silymarin polyphenols and its consequences for practical use in dermatology Pavel Kosina,...
Read More

J Agric Food Chem, 70, 20, 6134-6144 (2022)

IF 5,279 Interaction of Flavonoids with Zinc and Zinc-Containing Enzymes Marcel Hrubša, Václav Tvrdý, Michal Kutý, Kateřina Valentová, Vladimír Křen,...
Read More

INT J MOL SCI, 23, 10, 5743, 1-18 (2022)

IF 5,924 Sulfated Phenolic Substances: Preparation and Optimized HPLC Analysis Lucie Petrásková, Kristýna Káňová, Katerina Brodsky, Anastasiia Hetman, Barbora Petránková,...
Read More