Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

Biotechnology Advances 49, 107733 (2021)

IF 10,744 Advanced glycosidases as ingenious biosynthetic instruments Zuzana Mészáros, Pavlína Nekvasilová, Pavla Bojarová, Vladimír Křen, Kristýna Slámová Abstract Until...
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Biomedicine & Pharmacotherapy 138, 111459, 1-10 (2021)

IF 4,545 Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9, 2C19, 2D6,...
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Advanced Drug Delivery Reviews 171, 289-331 (2021)

IF 13,300 Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network Vinarov Zahari, Abrahamsson...
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International Journal of Molecular Sciences 22, 4, 1843 (2021)

IF 4,556 Growth Factors VEGF‐A165 and FGF‐2 as Multifunctional Biomolecules Governing Cell Adhesion and Proliferation Antonín Sedlář, Martina Trávníčková, Roman...
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BioTech 2020-2021

June 16-19,2021 Prague BioTech 2020 and 8th Czech-Swiss Symposium with exhibition will cover all important aspects of advanced biotechnologies. The...
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