Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

International Journal of Molecular Sciences, 22, 15, 7885, 1-45 (2021)

IF 5,923 Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners Vladimír Křen Abstract This review focuses on...
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International Journal of Molecular Sciences, 22, 10, 5144, 1-26 (2021)

IF 5,923 Interaction between Galectin-3 and Integrins Mediates Cell-Matrix Adhesion in Endothelial Cells and Mesenchymal Stem Cells Antonín Sedlář, Martina...
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International Journal of Molecular Sciences, 22, 13, 6661, 1-9 (2021)

IF 5,923   Reversible Lectin to Glycan-Functionalized Graphene Tereza Koukalová, Petr Kovaříček, Pavla Bojarová, Valentino L.P. Guerra, Vladimír Vrkoslav, Lukáš...
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Medicinal Research Reviews, 41, 4, 2195-2246 (2021)

IF 12,944 Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin Václav Tvrdý, Jana Pourová, Eduard Jirkovský,...
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Antioxidants, 10, 6, 954 (2021)

IF 6,312 Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-glucuronosyltransferases and Sulfotransferases Jiří...
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European Journal of Medicinal Chemistry 220, 113500 (2021)

IF 6,514 Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3  Viktoria Heine, Michaela Hovorková, Miluše Vlachová,...
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Food Chemistry, 357, 129757 (2021)

IF 7,514 Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds Dorrain Yanwen...
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Biotechnology Advances 49, 107733 (2021)

IF 14,227 Advanced glycosidases as ingenious biosynthetic instruments Zuzana Mészáros, Pavlína Nekvasilová, Pavla Bojarová, Vladimír Křen, Kristýna Slámová Abstract Until...
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Advanced Drug Delivery Reviews 171, 289-331 (2021)

IF 15,470 Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network Vinarov Zahari, Abrahamsson...
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