Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

NAT PROD REP, 43, 1, 200-226 (2026)

IF 10,6 Glycosylated mycotoxins: a hidden enemy Milena Stránská, Tomáš Řezanka, Vladimír Křen  Abstract Mycotoxins, secondary metabolites produced by filamentous...
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ACS Omega, 11, 1, 1620-1629 (2026)

IF 4,3 Glucuronidated Hydroxyphenylacetic and Hydroxyphenylpropanoic Acids as Standards for Bioavailability Studies with Flavonoids Janouchová Viola, Hurtová Martina, Kočová Vlčková...
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Talanta, 300, 129159 (2026)

IF 6,1 Colorimetric determination of the plant toxin β-cyano-L-alanine using amultistep enzyme reaction Ludmila Martínková, Romana Příhodová, Lenka Rucká, Michael...
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BIOMED PHARMACOTHER, 193, 118756 (2025)

IF 7,5 Galectin-3 as a therapeutic target in pulmonary hypertension: Molecular mechanisms, drug development directions, and emerging clinical applications Antonín...
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J AGR FOOD CHEM, 73, 43, 27622-27631 (2025)

IF 6,2 Discovery of a Novel Sucrose 6F-Phosphate Phosphorylase and Its Application for Isomelezitose Production Manon Steynen, Jorick Franceus, Davy...
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BioMACROMOLECULES, 26, 8, 4995-5009 (2025)

F 5,4 Human Milk Oligosaccharides Multivalently Presented on Defined Synthetic Neo-Glycoproteins Are Nanomolar Ligands of Tandem-Repeat Galectins Červený Jakub, Heine...
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