Laboratory of Biotransformation

Congratulations!

prestigious award “Lifetime Achievement”

Prof. Ing. Vladimír Křen, DrSc.

more information…

 

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

Int J Mol Sci, 23, 23, 15171, 1-16 (2022)

IF 6,208 Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis Viola Kolaříková, Katerina Brodsky, Lucie Petrásková, Helena Pelantová, Josef Cvačka,...
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Int J Mol Sci, 23, 23, 15121, 1-18 (2022)

IF 6,208 Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity Martina Hurtová, Kristýna Káňová, Simona Dobiasová, Kateřina Holasová, Denisa Čáková, Lan Hoang,...
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4th FBHC Prague 2023

  After the great success of the previous editions of the International Conference on Food Bioactives & Health and especially...
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Int J Mol Sci, 20, 23, 12456, 1-17 (2022)

IF 6,208 Mutation Hotspot for Changing the Substrate Specificity of β-N-Acetylhexosaminidase: A Library of GlcNAcases Pavlína Nekvasilová, Kulik Natalia, Michael...
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ChemSusChem 15, 18, e202201253, 1-9 (2022)

IF 9,140 Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors Katerina Brodsky,...
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„Lifetime Achievement“ Award

  10th International Congress on Biocatalysis (biocat), Hamburg, 28.8.-1.9.2022   At the International Congress on Biocatalysis, outstanding individuals are given...
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ChemComm 58, 63, 8838-8841 (2022)

IF 6,065 Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer’s disease Weber Patrick, Mészáros Zuzana, Jagečić Denis, Hribljan Valentina, Mitrečić Dinko, Bojarová Pavla, ...
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Bioorganic Chemistry, 127, 105983, 1-13 (2022)

IF 5,307 Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura...
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