Laboratory of Biotransformation

We are very pleased and proud to announce that the Head of our laboratory, Pavla Bojarová, was appointed Professor of Biomedical Engineering on 16 June 2025. The ceremonial handover of the professorial decree from the hands of the President of the Czech Republic took place in the Great Hall of the Carolinum.

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Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

BIOMED PHARMACOTHER, 193, 118756 (2025)

IF 7,5 Galectin-3 as a therapeutic target in pulmonary hypertension: Molecular mechanisms, drug development directions, and emerging clinical applications Antonín...
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J AGR FOOD CHEM, 73, 43, 27622-27631 (2025)

IF 6,2 Discovery of a Novel Sucrose 6F-Phosphate Phosphorylase and Its Application for Isomelezitose Production Manon Steynen, Jorick Franceus, Davy...
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BioMACROMOLECULES, 26, 8, 4995-5009 (2025)

F 5,4 Human Milk Oligosaccharides Multivalently Presented on Defined Synthetic Neo-Glycoproteins Are Nanomolar Ligands of Tandem-Repeat Galectins Červený Jakub, Heine...
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EUR J MED CHEM, 300, 118149:1-12 (2025)

IF 5,9 Targeting galectin-4 with glycoconjugates of varying architectures: a multivalency étude with accent on anti-tumor effect and protection against...
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International Journal of Nanomedicine, 20, 6591-6609 (2025)

IF 6,5 Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting  Monocytes and Preserving Interferon-Gamma Function Marcela Filipová, Marina Rodrigues...
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Journal of the Science of Food and Agriculture, 105 (5) 2765-2776 (2025)

IF 3,5 Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation...
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