Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

ChemCatChem, 14, 6, e202200037, 1-9 (2022)

IF 5,686 Targeted Fucosylation of Glycans with Engineered Bacterial Fucosyltransferase Variants Viktoria Heine, Helena Pelantová, Pavla Bojarová, Vladimír Křen, Lothar...
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INT J MOL SCI, 23, 8, 4106, 1-13 (2022)

IF 5,924  Engineered Glycosidases for the Synthesis of Analogs of Human Milk Oligosaccharides Pavlína Nekvasilová, Michaela Hovorková, Zuzana Mészáros, Lucie...
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INT J MOL SCI, 23, 7, 3462, 1-19 (2022)

IF 5,924  Laccases and Tyrosinases in Organic Synthesis Ludmila Martínková, Barbora Křístková, Vladimír Křen  Abstract Laccases (Lac) and tyrosinases (TYR)...
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ACS Catalysis, 12, 7, 3909-3922 (2022)

IF 13,084  A Career in Biocatalysis: Kurt Faber Vladimír Křen, Wolfgang Kroutil, Mélanie Hall Abstract Kurt Faber, a synthetic organic...
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Biomedicine & Pharmacotherapy, 149, 112806,1-14 (2022)

IF 6,530  Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureus Kateřina Holasová, Bára Křížskovská, Lan Hoang, Simona...
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Journal of Medicinal Chemistry, 65, 5, 3866-3878 (2022)

IF 7,446  Glycopolymers Decorated with 3‑O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin‑3 Vrbata David, Filipová Marcela, Tavares R. Marina,...
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Microorganisms, 10, 3, 549, 1-16 (2022)

IF 4,128  Metabolism of Aldoximes and Nitriles in Plant‐Associated Bacteria and Its Potential in Plant–Bacteria Interactions Robert Rädisch, Miroslav Pátek,...
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