Laboratory of Biotransformation

Congratulations!

prestigious award “Lifetime Achievement”

Prof. Ing. Vladimír Křen, DrSc.

more information…

 

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

Bioorganic Chemistry, 145, 107231:1-13 (2024)

IF 5,1 Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient David Vrbata, Jakub Červený, Natalia Kulik, Michaela Hovorková, Soňa Balogová,...
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Journal of Biotechnology, 382, 44-50 (2024)

IF 4,1 Cell-free reduction of carboxylic acids with secreted carboxylic acid reductase Dominic Goj, Stella Ebner, Melissa Horvat, Simon Arhar,...
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Organic Letters, 26, 3, 708-712 (2024)

IF 5,2 Multimodal Carbon Monoxide Photorelease from Flavonoids Andrea Ramundo, Martina Hurtová, Igor Božek, Zuzana Osifová, Marina Russo, Bokolombe Pitchou...
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Biomacromolecules, 24, 11, 4705-4717 (2023)

IF 6,2 Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin‑9 Binding: Increased Glycan Affinity to Galectins Correlates with...
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J AGR FOOD CHEM 71, 41, 14890-14910 (2023)

IF 6,1 Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry Michael Kotík, Natalia Kulik, Kateřina Valentová  Abstract...
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