Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.
Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…
News from lab
By capkova
/ 18. 7. 2024
IF 3,7 Biotransformation of free cyanide to formic acid by a cyanide hydratase-formamidase cascade reaction Ludmila Martínková, Natalia Kulik, Lenka...
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By capkova
/ 6. 6. 2024
IF 5,1 Diaminocyclopentane – L-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase Patrick Weber, Pavla Bojarová, Jitka Brouzdová, Vladimír...
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By capkova
/ 5. 6. 2024
IF 5,1 Synthesis and unexpected binding of monofluorinated N, N‘-diacetylchitobiose and LacdiNAc to wheat germ agglutinin Hana Kaci, Éva Bakos,...
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By capkova
/ 22. 3. 2024
IF 4,6 The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1...
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By capkova
/ 22. 3. 2024
IF 5,8 Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation Z. Dostál, A.V. Zholobenko,...
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By capkova
/ 21. 3. 2024
IF 4,1 Immobilization of aldoxime dehydratases on metal affinity resins and use of the immobilized catalysts for the synthesis of...
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