Doc. RNDr. Pavla Bojarová, PhD.

Position:
Senior Scientist, Head of the Laboratory
Email:
bojarova@biomed.cas.cz
pavla.bojarova@fbmi.cvut.cz
Phone:
(+420) 296 442 360
Address/Affilliation:
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
CZ 142 00 Praha 4 
Czech Republic
Faculty of Biomedical Engineering
Czech Technical University in Prague
nám. Sítná 3105
CZ 272 01 Kladno
Czech Republic

 

Employment

Since 2021 Deputy head of the Laboratory of Biotransformation
Since 2020 Habilitation at Faculty of Biomedical Engineering, Czech Technical University in Prague, habilitation thesis: Novel glyco-nanomaterials for biomedicine and biotechnology
Since 2019 Lecturer at Faculty of Biomedical Engineering, Czech Technical University in Prague
Since 2010 Lecturer at Department of Biochemistry, Faculty of Science, Charles University in Prague (Biochemistry and Biomedicine of Carbohydrates)
Since 2008 Research fellow in the Laboratory of Biotransformation
2006–2007 Postdoctoral stay at the University of Melbourne, Australia
Since 1999 member of the Laboratory of Biotransformation

Education

Study stays

Year Institute Length
2010 Helmholtz-Institut für Biomedizinische Technik, RWTH Aachen 2 weeks
2006–7 School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Australia 13 mths
2006 Directed Enzyme Evolution Course, Inst. Biotechnology, Vilnius 1 week
2005 Helmholtz-Institut für Biomedizinische Technik, RWTH Aachen 7 weeks
2005 Istituto di Chimica del Riconoscimento Molecolare, CNR, Milan 4 weeks
2003 Helmholtz-Institut für Biomedizinische Technik, RWTH Aachen 3 mths
2003 Departamento de Quimica organica, Fac.de Quimica, Univ. de Sevilla 4 weeks
2002 Institut für Organische Chemie, Universität Hamburg 4 weeks

Prizes & Awards

07/2024 invited lecture in the 31th International Carbohydrate Symposium (Shanghai, China)
05/2024 invited lecture in the 15th Carbohydrate Bioengineering Meeting (Ghent, Belgium)
Since 2023 National representative of the Czech Republic in the European Carbohydrate Organization (ECO)
2022-2026 Elected member of the Academy Assembly of the Czech Academy of Sciences
06/2022 invited lecture in the 15th Bratislava Symposium on Saccharides, (Smolenice, Slovakia)
2019 the prize of the Director of the Institute if Microbiology of the Czech Academy of Sciences, for the best review article
08/2018 invited plenary lecture in the 9th International Congress on Biocatalysis
07/2018 invited lecture in the 29th International Carbohydrate Symposium
2013 the prize of the Director of the Institute of Microbiology of the Czech Academy of Sciences for the best review article
2010, 2012 finalist of the scholarship program L´Oréal Women in Science
2006 the best dissertation thesis in the Institute of Microbiology of the Czech Academy of Sciences

Publications & Presentations

  • 80 papers
  • 4 book chapters
  • 3 patents
  • 1953 citations (Web of Science, All databases)
  • H-index 25
  • (Co-)author of ca 60 oral or poster presentations in international conferences in the last 10 years

Areas of interest

My team is primarily involved in the study of oligosaccharides and glycomimetivs, in their multivalent presentation on various carriers and in the analysis of the properties of the prepared glycoconjugates, especially concerning their interaction with biomedically attractive lectins. At present we are concentrating on galectins and their involvement in tumorigenesis and cardiopathologies. For oligosaccharide synthesis we use chemo-enzymatic synthesis with novel enzymatic tools, which gained favorable synthetic properties or altered substrate specificity through site directed mutagenesis. We study the affinity of glycoconjugates to lectins and lectin-overexpressing cells with a whole series of methods, such as NMR, immunochemistry, biolayer interferometry and flow cytometry.

Patents

  • Institute of Macromolecular Chemistry and Institute of Microbiology, Czech Academy of Sciences. Glycopolymer, a method of its preparation and its use as a medicine. P. Bojarová, T. Vašíček, P. Chytil, M. Filipová, O. Janoušková, T. Etrych a M. Tavares. Patent 309634, Czech Republic, May 29, 2023.
  • Institute of Macromolecular Chemistry and Institute of Microbiology, Czech Academy of Sciences. Glycopolymer, a method of its preparation and its use as a medicine. P. Bojarová, T. Vašíček, P. Chytil, M. Filipová, O. Janoušková, T. Etrych a M. Tavares. Patent 309738, Czech Republic, August 31, 2023.
  • Institute of Macromolecular Chemistry and Institute of Microbiology, Czech Academy of Sciences. Glycopolymer, a method of its preparation and its use as a medicine. P. Bojarová, T. Vašíček, P. Chytil, M. Filipová, O. Janoušková, T. Etrych a M. Tavares. Patent 309740, Czech Republic, April 20, 2023.

Selected publications (last 6 years)

  • Patrick Weber, Pavla Bojarová, Jitka Brouzdová, Vladimír Křen, Natalia Kulik, Arnold E. Stütz, Martin Thonhofer, Tanja M. Wrodnigg: Diaminocyclopentane – L-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase. Bioorganic Chemistry, 148, July 2024, 107452: 1-12 (2024).
  • Martin Kurfiřt, Vojtěch Hamala, Jan Beránek, Lucie Červenková Šťastná, Jakub Červený, Martin Dračínský, Jana Bernášková, Vojtěch Spiwok, Zuzana Bosáková, Pavla Bojarová, Jindřich Karban: Synthesis and unexpected binding of monofluorinated N, N‘-diacetylchitobiose and LacdiNAc to wheat germ agglutinin. Bioorganic Chemistry, 147, June 2024, 107395: 1-12 (2024).
  • David Vrbata, Jakub Červený, Natalia Kulik, Michaela Hovorková, Soňa Balogová, Miluše Vlachová, Helena Pelantová, Vladimír Křen, Pavla Bojarová: Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient. Bioorganic Chemistry, 145, April 2024, 107231: 1-13 (2024)
  • Monika Müllerová, Michaela Hovorková, Táňa Závodná, Lucie Červenková Šťastná, Alena Krupková, Vojtěch Hamala, Kateřina Nováková, Jan Topinka, Pavla Bojarová, Tomáš Strašák: Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin‑9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior. Biomacromolecules, 24 (11), 4705-4717 (2023).
  • Miluše Vlachová, Van Nguyen Tran, Jakub Červený, František Dolníček, Lucie Petrásková, Helena Pelantová, Ondřej Kundrát, Josef Cvačka, Zuzana Bosáková, Vladimír Křen, Pavel Lhoták, Jitka Viktorová, Pavla Bojarová: Galectin-targeting glycocalix[4]arenes can enter the cells†. Chemical Communications, 59, 10404-10407 (2023)
  • Patrick Weber, Zuzana Mészáros, Pavla Bojarová, Manuel Ebner, Roland Fischer, Vladimír Křen, Natalia Kulik, Philipp Müller, Miluše Vlachová, Kristýna Slámová, Arnold E. Stütz, Martin Thonhofer, Ana Torvisco, Tanja M. Wrodnigg, Andreas Wolfsgruber: Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase. Bioorganic Chemistry, 140, November 2023, 106819: 1-14 (2023)
  • Vladimír Křen, Pavla Bojarová: Rutinosidase and other diglycosidases: Rising stars in biotechnology. Biotechnology Advances, 68, November 2023, 108217: 1-20 (2023)
  • Kristýna Slámová, Jakub Červený, Zuzana Mészáros, Tereza Friede, David Vrbata, Vladimír Křen, Pavla Bojarová: Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly. Molecules, 28 (10), 4039: 1-15 (2023). 
  • Michaela Hovorková, Jakub Červený, Ladislav Bumba, Helena Pelantová, Josef Cvačka, Vladimír Křen, Olivier Renaudet, David Goyard, Pavla Bojarová: Advanced high-affinity glycoconjugate ligands of galectins. Bioorganic Chemistry, 131 (February 2023), 106279: 1-12 (2023)
  • Ludmila Martínková, Natalia Kulik, Anastasia Sedova, Barbora Křístková, Pavla Bojarová: Recent Progress in the Production of Cyanide-Converting Nitrilases-Comparison with Nitrile-Hydrolyzing Enzymes. Catalysts, 13 (3), 500:1-19 (2023).
  • Renáta Novotná, Denisa Škařupová, Jiří Hanyk, Jitka Ulrichová, Vladimír Křen, Pavla Bojarová, Katerina Brodsky, Jitka Vostálová, Jana Franková: Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents. Molecules, 28 (4), 1728:1-14 (2023).
  • Dorota Konvalinková, František Dolníček, Michaela Hovorková, Jakub Červený, Ondřej Kundrát, Helena Pelantová, Lucie Petrásková, Josef Cvačka, Margarita Faizulina, Beena Varghese, petr Kovaříček, Vladimír Křen, Pavel Lhoták, Pavla Bojarová: Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters. Organic & Biomolecular Chemistry, 21 (6), 1294-1302 (2023). 
  • Ludmila Martínková, Pavla Bojarová, Anastasia Sedova, Vladimír Křen: Recent trends in the treatment of cyanide-containing effluents: Comparison of different approaches. Critical reviews in environmental science and technology, 53 (3), 416-434 (2023).
  • Mariann Kiss, István Timári, Teréz Barna, Zuzana Mészáros, Kristýna Slámová, Pavla Bojarová, Vladimír Křen, Joseph M. Hayes, László Somsák: 2-Acetamido-2-deoxy-D-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes. International Journal of Molecular Sciences, 23 (3), 1037 1-19 (2022).
  • Pingitore Valeria, Martínez-Bailén Macarena, Carmona T. Ana, Mészáros Zuzana, Kulik Natalia, Slámová Kristýna, Křen Vladimír, Bojarová Pavla, Robina Inmaculada, Moreno-Vargas J. Antonio: Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars. Bioorganic Chemistry, 120, 105650:1-12 (2022).
  • Vrbata David, Filipová Marcela, Tavares R. Marina, Červený Jakub, Vlachová Miluše, Šírová Milada, Pelantová Helena, Petrásková Lucie, Bumba Ladislav, Konefal Rafal, Etrych Tomáš, Křen Vladimír, Chytil Petr, Bojarová Pavla: Glycopolymers Decorated with 3‑O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin‑3. Journal of medicinal Chemistry, 65 (5), 3866-3878 (2022).
  • Pavlína Nekvasilová, Michaela Hovorková, Zuzana Mészáros, Lucie Petrásková, Helena Pelantová, Vladimír Křen, Kristýna Slámová, Pavla Bojarová: Engineered Glycosidases for the Synthesis of Analogs of Human Milk Oligosaccharides. International Journal of Molecular Sciences, 23 (8), 4106:1-13 (2022).
  • Viktoria Heine, Helena Pelantová, Pavla Bojarová, Vladimír Křen, Lothar Elling: Targeted Fucosylation of Glycans with Engineered Bacterial Fucosyltransferase Variants. ChemCatChem, 14 (6), e202200037:1-9 (2022).
  • Viktoria Heine, Carina Dey, Pavla Bojarová, Vladimír Křen, Lothar Elling: Methods of in vitro study of galectin-glycomaterial interaction. Biotechnology Advances, 58, 107928: 1-23 (2022).
  • Zuzana Mészáros, Lucie Petrásková, Natalia Kulik, Helena Pelantová, Pavla Bojarová, Vladimír Křen, Kristýna Slámová: Hypertransglycosylating Variants of the GH20 β-N-Acetylhexosaminidase for the Synthesis of Chitooligomers. Advanced Synthesis & Catalysis, 364 (12), 2009-2022 (2022).
  • Patrick Weber, Zuzana Mészáros, Denis Jagečić, Valentina Hribljan, Dinko Mitrečić, Pavla Bojarová, Kristýna Slámová, Jiří Vrba, Natalia Kulik, Vladimír Křen, Arnold E. Stütz: Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer’s disease. Chemical Communications, 58 (63), 8838-8841 (2022).
  • Katerina Brodsky, Kristýna Káňová, Dorota Konvalinková, Kristýna Slámová, Helena Pelantová, Kateřina Valentová, Pavla Bojarová, Vladimír Křen, Lucie Petrásková: Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors. ChemSusChem, 15 (18), e202201253: 1-9 (2022).
  • Pavlína Nekvasilová, Kulik Natalia, Michael Kotík, Lucie Petrásková, Kristýna Slámová, Vladimír Křen, Pavla Bojarová: Mutation Hotspot for Changing the Substrate Specificity of β-N-Acetylhexosaminidase: A Library of GlcNAcases. International Journal of Molecular Sciences, 23 (20), 12456: 1-17 (2022).
  • Kotík Michael, Brodsky Katerina, Halada Petr, Javůrková Hana, Pelantová Helena, Konvalinková Dorota, Bojarová Pavla, Křen Vladimír: Acces to both anomers of rutinosyl azide using wild-type rutinosidase and its catalytic nucleophile mutant. Catalysis Communications, 149, 106193 1-5 (2021).
  • Sedlář Antonín, Trávníčková Martina, Matějka Roman, Pražák Šimon, Mészáros Zuzana, Bojarová Pavla, Bačáková Lucie, Křen Vladimír, Slámová Kristýna: Growth Factors VEGF-A165 and FGF-2 as Multifunctional Biomolecules Governing Cell Adhesion and Proliferation. International Journal of Molecular Sciences, 22 (4), 1843 1-27 (2021).
  • Mészáros Zuzana, Nekvasilová Pavlína, Bojarová Pavla, Křen Vladimír, Slámová Kristýna: Advanced glycosidases as ingenious biosynthetic instruments. Biotechnology Advances, 49, 107733, 1-27 (2021).
  • Heine Viktoria, Hovorková Michaela, Vlachová Miluše, Filipová Marcela, Bumba Ladislav, Janoušková Olga, Hubálek Martin, Cvačka Josef, Petrásková Lucie, Pelantová Helena, Křen Vladimír, Elling Lothar, Bojarová Pavla: Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3. European Journal of Medicinal Chemistry, 220, 113500, 1-10 (2021).
  • Sara Bertuzzi, Ana Gimeno, Ane Martinez-Castillo, Marta G. Lete, Sandra Delgado, Cristina Airoldi, Marina Rodrigues Tavares, Markéta Bláhová, Petr Chytil, Vladimír Křen, Nicola G.A. Abrescia, Ana Ardá, Pavla Bojarová, Jesús Jiménez-Barbero: Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers. International Journal of Molecular Sciences, 22 (11), 6000, 1-17 (2021).
  • Tereza Koukalová, Petr Kovaříček, Pavla Bojarová, Valentino L. P. Guerra, Vladimír Vrkoslav, Lukáš Navara, Ivan Jirka, Marek Cebecauer, Vladimír Křen, Martin Kalbáč: Reversible Lectin Binding to Glycan-Functionalized Graphene. International Journal of Molecular Sciences, 22 (13), 6661, 1-9 (2021)
  • Antonín Sedlář, Martina Trávníčková, Pavla Bojarová, Miluše Vlachová, Kristýna Slámová, Vladimír Křen, Lucie bačáková: Interaction between Galectin-3 and Integrins Mediates Cell-Matrix Adhesion in Endothelial Cells and Mesenchymal Stem Cells. International Journal of Molecular Sciences, 22 (10), 5144, 1-26 (2021)
  • Martin Kurfiřt, Martin Dračínský, Lucie Červenková Šťastná, Petra Cuřínová, Vojtěch Hamala, Michaela Hovorková, Pavla Bojarová, Jindřich Karban: Selectively Deoxyfluorinated N-Acetyllactosamine Analogues as 19F NMR Probes to Study Carbohydrate-Galectin Interactions. Chemistry-A European Journal, 27 (51), 13040-13051 (2021).
  • Michaela Hovorková, Natalia Kulik, Dorota Konvalinková, Lucie Petrásková, Vladimír Křen, Pavla Bojarová: Mutagenesis of Catalytic Nucleophile of β-Galactosidase Retains Residual Hydrolytic Activity and Affords a Transgalactosidase. ChemCatChem, 13 (21), 4532-4542 (2021).
  • Anastasia Sedova, Lenka Rucká, Pavla Bojarová, Michaela Glozlová, Petr Novotný, Barbora Křístková, Miroslav Pátek, Ludmila Martínková: Application Potential of Cyanide Hydratase from Exidia Glandulosa: Free Cyanide Removal from Simulated Industrial Effluents. Catalysts, 11 (11), 1410:1-16 (2021).
  • Nekvasilová Pavlína, Andreasová Iveta, Petrásková Lucie, Pelantová Helena, Křen Vladimír, Bojarová Pavla: A novel enzymatic tool for transferring GalNAc moiety onto challenging acceptors. BBA – Proteins and Proteomics, 1868 (2), 140319:1-8 (2020).
  • Tavares Marina Rodrigues, Bláhová Markéta, Sedláková Lieselotte, Elling Lothar, Pelantová Helena, Konefal Rafal, Etrych Tomáš, Křen Vladimír, Bojarová Pavla, Chytil Petr: High-Affinity N-(2-Hydroxylpropyl)methacrylamide Copolymers with Tailored N-Acetyllactosamine Presentation Discriminate between Galectins. Biomacromolecules, 21 (2), 641-652 (2020).
  • Jana Kapešová, Lucie Petrásková, Natalia Kulik, Zuzana Straková, Pavla Bojarová, Kristína Markošová, Martin Rebroš, Vladimír Křen, Kristýna Slámová: Transglycosidase activity of glycosynthase-type mutants of a fungal GH20 β-N-acetylhexosaminidase. International Journal of Biological Macromolecules, 161, 1206-1215 (2020).
  • Petr Pachl, Jana Kapešová, Jiří Brynda, Lada Biedermannová, Helena Pelantová, Pavla Bojarová, Vladimír Křen, Pavlína Řezáčová, Michael Kotík: Rutinosidase from Aspergillus niger: crystal structure and insight into the enzymatic activity. The FEBS Journal, 287 (15), 3315-3327 (2020).
  • Katerina Brodsky, Michal Kutý, Helena Pelantová, Josef Cvačka, Martin Rebroš, Michael Kotík, Ivana Kutá Smatanová, Vladimír Křen, Pavla Bojarová: Dual Substrate Specificity of the Rutinosidase from Aspergillus niger and the Role of Its Substrate Tunnel. International Journal of Molecular Sciences, 21 (16), 5671: 1-21 (2020).
  • Vladimír Křen, Pavla Bojarová: Editorial: Biocatalysis: „A Jack of all Trades…“. International Journal of Molecular Sciences, 21 (14), 5115: 1-3 (2020).
  • Marcela Filipová, Pavla Bojarová, Marina Rodrigues Tavares, Ladislav Bumba, Lothar Elling, Petr Chytil, Kristýna Gunár, Vladimír Křen, Tomáš Etrych, Olga Janoušková: Glycopolymers for Efficient Inhibition of Galectin-3: In Vitro Proof of Efficacy Using Suppression of T Lymphocyte Apoptosis and Tumor Cell Migration. Biomacromolecules, 21 (8), 3122-3133 (2020).
  • Tomáš Vašíček, Vojtěch Spiwok, Jakub Červený, Lucie Petrásková, Ladislav Bumba, David Vrbata, Helena Pelantová, Vladimír Křen, Pavla Bojarová: Regioselective 3-O-Substitution of Unprotected Thiodigalactosides: Direct Route to Galectin Inhibitors. Chemistry-A European Journal, 26 (43), 9620-9631 (2020).
  • Pavlína Nekvasilová, Natalia Kulik, Nikola Rychlá, Helena Pelantová, Lucie Petrásková, Zuzana Bosáková, Josef Cvačka, Kristýna Slámová, Vladimír Křen, Pavla Bojarová: How Site-Directed Mutagenesis Boosted Selectivity of a Promiscuous Enzyme. Advanced Synthesis and Catalysis, 362 (19), 4138-4150 (2020).
  • Bojarová Pavla, Kulik Natalia, Hovorková Michaela, Slámová Kristýna, Pelantová Helena, Křen Vladimír: The β-N-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering. Molecules, 24 (3), 599, 1-14 (2019)
  • Bojarová Pavla, Kulik Natallia, Slámová Kristýna, Hubálek Martin, Kotík Michael, Cvačka Josef, Pelantová Helena, Křen Vladimír: Selective β-N-acetylhexosaminidase from Aspergillus versicolor—a tool for producing bioactive carbohydrates. Applied Microbiology and Biotechnology, 103 (4), 1737-1753 (2019)
  • Kapešová Jana, Petrásková Lucie, Markošová Kristína, Rebroš Martin, Kotík Michael, Bojarová Pavla, Křen Vladimír: Bioproduction of Quercetin and Rutinose Catalyzed by Rutinosidase: Novel Concept of „Solid State Biocatalysis“. International Journal of Molecular Sciences, 20 (5), 1112 (1-15) (2019).
  • Laaf Dominic, Bojarová Pavla, Elling Lothar, Křen Vladimír: Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology. Trends in Biotechnology, 37 (4), 402-415 (2019).
  • Bassanini Ivan, Kapešová Jana, Petrásková Lucie, Pelantová Helena, Markošová Kristína, Rebroš Martin, Valentová Kateřina, Kotík Michael, Káňová Kristýna, Bojarová Pavla, Cvačka Josef, Turková Lucie, Ferrandi E. Erica, Bayout Ikram, Riva Sergio, Křen Vladimír: Glycosidase-Catalyzed Synthesis of Glycosyl Esters and Phenolic Glycosides of Aromatic Acids. Advanced Synthesis and Catalysis, 361 (11), 2627-2637 (2019).
  • Bojarová Pavla, Bruthans Jan, Křen Vladimír: β-N-Acetylhexosaminidases-the wizards of glycosylation. Applied Microbiology and Biotechnology, 103 (19), 7869-7881 (2019).
  • Garcia-Oliva Cecilia, Hoyos Pilar, Petrásková Lucie, Kulik Natalia, Pelantová Helena, Cabanillas H. Alfredo, Rumbero Ángel, Křen Vladimír, Hernáiz J. María, Bojarová Pavla: Acceptor Specificity of β-N-Acetylhexosaminidase from Talaromyces flavus: A Rational Explanation. International Journal of Molecular Sciences, 20 (24), 6181: 1-17 (2019).
  • Bumba L., Laaf D., Spiwok V., Elling L., Křen V., Bojarová P.: Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling. International Journal of Molecular Sciences, 19 (2), 372:1-17 (2018).
  • Bojarová P., Tavares M.R., Laaf D., Bumba L., Petrásková L., Konefal R., Bláhová M., Pelantová H., Elling L., Etrych T., Chytil P., Křen V.: Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3. Journal of Nanobiotechnology, 16:73, (1-16) (2018).

Grant projects

  • LUC23148 Glycopolymer inhibitors of galectins for immunotherapy (2023-2026)
  • LUC23149 Galectins as biomarkers of pancreatic cancer (2023-2026)
  • NU23-08-00307 Galectin-positive glioblastoma exosomes: new biomarkers and targets for glycoanotherapeutics (2023-2026)
  • 22-00262S Advanced high-molecular-weight glycopolymers as potent inhibitors of galectin-induced pathological processes (2022-2024)
  • 22-00317S Galectin-3 as a target molecule for the reversal of vascular remodelling in hypoxic pulmonary hypertension (2022-2024)
  • LTC20072 Library of engineered glycosidases for the preparation of bioactive glycans (2020-2023)
  • 20-00215S Neutral oligosaccharides of human milk as ligands of galectins (2020-2023)
  • LTC19038 Targeted glyco-nanomaterials for diagnosis and therapy of cancer (2019-2022)
  • LTC18038 Multivalent glyco-biomaterials with a potential in regeneration medicine (2018-2021)
  • LTC17005 Multivalent glycopolymers as ligands of lectin-denoted biological targets (2017-2020)

Membership in international consortia

  • CA22103 A comprehensive network against brain cancer (Net4Brain)
  • CA21135 Modelling immunotherapy response and toxicity in cancer (IMMUNO-model) 
  • CA21116 Identification of biological markers for prevention and translational medicine in pancreatic cancer (TRANSPAN) 
  • CA20117 Converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer (Mye-InfoBank) 
  • CA18132 Functional glyconanomaterials for the development of diagnostics and targeted therapeutic probes (GLYCONanoPROBES)
  • CA18103 Innovation with glycans: new frontiers from synthesis to new biological targets (INNOGLY)
  • CA17140 Cancer nanomedicine – from the bench to the bedside (NANO2CLINIC)
  • CA16122 Biomaterials and advanced physical techniques for regenerative cardiology and neurology (BIONECA)
  • CA15135 Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig)

Students & Teaching

  • 1 defended Ph.D. student
  • 5 active Ph.D. students 
  • 2 active Master students (7 defended)
  • 3 active Bachelor students (21 defended)

Faculty of Biomedical Engineering, Czech Technical University in Prague (FBMI ČVUT):

  • Environmentální bezpečnost, prezenční forma (17PBPENV)
  • Environmentální bezpečnost, kombinovaná forma (17KBP2ENB)

Participating also in:

  • Obecné laboratorní dovednosti (17PBLOLD)
  • Základy patologie, hygieny a epidemiologie (17PBBZPD)
  • Fundamentals of Pathophysiology & Diagnostic Methods (17AMBZPD)
  • Základy klinických oborů I (17KBIKO1)
  • Základy preklinické medicíny II (17PBIPM2)
  • Základy radiobiologie a možná zneužití radiačních a biologických agens (17PBPZRRBA)
  • Integrovaný záchranný systém a medicína katastrof (F7PMSIZS)
  • Biologická ochrana (F7PBPBO)
  • Klinická biochemie II (F7PBLKBCH2)

Department of Biochemistry, Faculty of Science, Charles university (PřF UK)

  • Biochemie a biomedicína sacharidů (MC250P64)
  • Pokročilé praktikum II (MC250C08)

My core team

Organic synthesis: Mgr. David Vrbata, PhD., Mgr. Andrea Vopálenská

Analytical chemistry: Mgr. Jakub Červený

Biochemistry, molecular biology: Mgr. Pavlína NekvasilováIng. Katerina Brodsky, Mgr. Michaela Hovorková, Bc. Soňa Balogová, Mgr. Alena Hrdličková

Biotechnology: Bc. Eliška Filipová

Biology: Ing. Miluše Vlachová, PhD., Mgr. Anna Loginova, PhD.

Past team members (last 5 years): Ing. Tereza Strnadová Koukalová, Mgr. Tomáš Vašíček, Bc. Lieselotte Sedláková, Bc. Iveta Andreasová, Bc. Nikola Rychlá, Mgr. Veronika Libová, RNDr. Barbora Mikulová, BSc. Petr Brož, Ing. Dorota Konvalinková, MSc.Viktoria Heine, Mgr. Barbora Petránková, Mgr. Michaela Glozlová, Mgr. Anastasia Sedova, Bc. Tereza Friedová, Ing. Zuzana Mészáros, PhD.

What´s up

  • I am the Head of the Organizational Committee of Eurocarb 2029 held in Prague
  • Our team organizes Training School on Brain Cancer Study and Data Integration in April 24-26 in Prague (COST Action CA22103)
  • I was awarded Invited lecture at 31th International Carbohydrate Symposium (Shanghai, July 2024)
  • I was awarded Invited lecture at 15th Carbohydrate Bioengineering Meeting (Ghent, Belgium, May 2024)
  • I was a member of the Organizational Committee of of 4th International Conference on Food Bioactives and Health, September 18-21, Prague https://fbhc2023.com/
  • I am Assistant Editor of the journal Folia Microbiologica (Springer)
  • We welcome students at all levels to join us for their Bachelor, Master or Dissertation Thesis

Snapshots from the life of our team

 

Last update: June 6, 2024