Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

Biomaterials Science, 13 (6), 1482-1500 (2025)

IF 5,8 Color-coded galectin fusion proteins as novel tools in biomaterial science† Dey Carina, Sommerfeld Isabel K., Bojarová Pavla, Kodra...
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Scientific Reports, 15, 5631:1-13 (2025)

IF 3,8 Flavonolignans silybin, silychristin and 2,3-dehydrosilybin showed differential cytoprotective, antioxidant and anti-apoptotic effects on splenocytes from Balb/c mice Zuzana...
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Anal. Bioanal. Chem., 417 (4), 697-704 (2025)

IF 3,8 Design and development of spectrophotometric enzymatic cyanide assays Katarína Šťastná, Ludmila Martínková, Lenka Rucká, Barbora Křístková, Romana Příhodová,...
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J. Agric. Food Chem., 73 (2), 1308-1318 (2025)

IF 5,7 Carbon Monoxide-Releasing Activity of Plant Flavonoids Muchová Lucie, Šranková Mária, Balasubramani Sriram, Mehta Panshul, Vlachopoulou Dafni, Kapoor Akshat,...
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Carbohydrate Research, 548, February 2025, 109337:1-9

IF 2,4 Recent trends in the separation and analysis of chitooligomers Lucie Petrásková, Pavla Bojarová  Abstract Chitosan is a widely...
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Frontiers in Physiology, 15, 1489439:1-15 (2024)

IF 3,2 Nutraceuticals Silybin B, resveratrol, and epigallocatechin-3 gallate (EGCG) bind to cardiac muscle troponin to restore the loss of...
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