Laboratory of Biotransformation

Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.

Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…

 


News from lab

Molecular Nutrition & Food Research, 2400500 (1-14) (2024)

IF 4,5 Mutual Interactions of Silymarin and Colon Microbiota in Healthy Young and Healthy Elder Subjects Tomisová Kateřina, Jarošová Veronika,...
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Structure, 32, 1-15 (2024)

IF 4,4 The variable structural flexibility of the Bacillus circulans β-galactosidase isoforms determines their unique functionalities Michaela Hovorková, Barbora Kaščáková,...
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Journal of Agricultural and Food Chemistry, 72 (40), 22208-22216 (2024)

IF 5,7 New Bacterial Aryl Sulfotransferases: Effective Tools for Sulfation of Polyphenols Katerina Brodsky, Barbora Petránková, Lucie Petrásková, Helena Pelantová,...
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Pharmacology Research & Perspectives, 12 (5), e70021: 1-12 (2024)

IF 2,9 Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4)...
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ACS Omega, 9, 32, 34938-34950 (2024)

IF 3,7 Nitrogen-Containing Flavonoids–Preparation and Biological Activity Martina Hurtová, Daniela Brdová, Bára Křížskovská, Guglielmo Tedeschi, Tomáš Nejedlý, Ondřej Strnad, Simona...
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ChemCatChem, 16, 11, e202400028: 1-7 (2024)

IF 3,8 Expanding Rutinosidase Versatility: Acylated Quercetin Glucopyranosides as Substrates Katerina Brodsky, Lucie Petrásková, Michal Kutý, Pavla Bojarová, Helena Pelantová,...
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