„White team“ (Glycobiology)
- Library of fungal glycosidases – new enzymes and application for glycobiological problems
- Diglycosidases/Rutinosidases
- Engineered Glycosidases as Synthetic Tools
“Blue team“ (Nitrile Biotransformations)
- Biotransformation by enzymes of the nitrile metabolism
- Remediation of cyanide wastes
- Biotransformations by laccases and tyrosinases
“Yellow Team“ (Flavonoids and Metabolomics)
- Flavonolignans from the Milk thistle – short introduction
- Separation of silybin diastereoisomers
- Flavonolignans as modulators of multidrug resistance
- Preparation of synthetic and natural flavonoids
- Minor and neglected flavonolignans and metabolites
- Biophysical and biological activity of flavonoids and their metabolites
- Hybrid molecules and other derivatives
- Aryl-sulfotransferases and their application in sulfated metabolite preparation
- Metabolites of phenolic compounds
Inovative Methodologies
- Analytical methods
- Bio-layer interferometry (BLI)
- Cell cultures
Completed Projects
- Preparation of multivalent derivatives of ergot alkaloids and their pharmacological studies
- Epoxide hydrolases
- The ways to N-acetylmannosamine structures via mannoside metabolizing enzymes
- Microbial communities and haloalkane dehalogenases
- Preparation of silybin lipophilic derivatives and evaluation of their biological activities
- Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity
- Modified substrates for β-N-acetylhexosaminidases: Application in synthesis and mechanistic studies
Doc. Ing. Kateřina Valentová, PhD.