Doc. Ing. Kateřina Valentová, PhD.

Position:
Senior Scientist
Email:
kata.valentova@email.cz
katerina.valentova@biomed.cas.cz
Phone:
(+420) 296 442 509
Address:
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
Prague 4 – Krč
142 20
Czech Republic

Education

  • Institute of Chemical Technology in Prague (Biochemistry) – MSc. (2000)
  • Faculty of Medicine, Palacký University, Olomouc (Medical Chemistry and Biochemistry) – Ph.D. (2004)
  • Faculty of Medicine, Palacký University, Olomouc (Medical Chemistry and Biochemistry) – Associate Professor (2012)

Positions

  • 2003–2004 Research Assistant
  • 2004–2012 Assistant Professor
  • 2013 (01–08) Associate Professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic
  • Since 2013(09) Member of the Laboratory of Biotransformation

Research Orientation

  • Metabolism and biotransformation of polyphenols
  • Biological activity of natural substances and plant extracts
  • Free radicals and their scavenging
  • Antioxidant and cytoprotective activity
  • Lipid peroxidation
  • Glucose metabolism
  • Hepatocytes, HUVEC
  • Angiogenesis

Experience

  • 1999 (1 month) Department of Clinical Biochemistry, Olomouc Teaching Hospital.
  • 1999 (3 months) Laboratory of Heterocycles and Glucides Chemistry, University Blaise Pascal, Clermont-Ferrand, France
  • 2001 (1 week) Ivax-Pharmaceuticals Co., Opava
  • 2002 (2 months) Laboratory of Molecular Biology and Physiology of the Vein, INSERM U541, Paris, France
  • 2003 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
  • 2004 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
  • 2005 (3 weeks) Laboratory of Molecular Toxicology, INSERM U490, Paris, France
  • 2006 (2 weeks) INSERM U775, Paris, France
  • 2012 (1 week) Université de Lille 2, France
  • 2013 (1 week) University of Colorado, USA
  • 2017 (1 week) ITQB NOVA, Oeiras, Portugal

Courses

  • 1998–2000 Teaching of chemistry for high schools, Institute of Chemical Technology, in Prague, Czech Republic.
  • 2001 ACS Workshop, How to develop, Validate and Troubleshoot GS & HPLC Methods.
  • 2002 Chemistry and Biochemistry of Natural Compounds, Czech Academy of Science.
  • 2003 Good Research Practice in Biomedicine, Biological and Veterinary Sciences, international I-workshop for Ph.D. students.

Membership

  • 2000 Czech Chemical Society
  • 2006 Phytochemical Society of Europe
  • 2006 Czech Society for Probiotics and Prebiotics

Awards

  • 2003 Pharmacy Price, Aventis and French Embassy in Prague
  • 2003 Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication

Languages

  • French
  • English

Projects

  • GA18-00132S: Inter-individual variability in the metabolism of silymarin flavonolignans in humans (2018-2021)
  • GA18-00121S: The role of optically pure flavonolignans in cardiovascular effects of silymarin (2018-2021)
  • COST CA17104 – New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM, 2018-2022)
  • LTC19039: Gastrointestinal transformations of polyphenolic drugs (2019-2021)
  • COST Action CA16205 – European network on understanding gastrointestinal absorption-related processes (UNGAP, 2017-21)
  • GA15–03037S – Dehydro-derivatives of the silymarin flavonolignans: metabolism and biological activity (2015–2017)
  • LTC18003: Metabolism of silymarin flavonolignans in aging population (2018-2021)
  • COST Action CA16112: Personalized Nutrition in aging society: redox control of major age-related diseases (NutRedOx, 2017–2021)
  • LD15082 – Chemoenzymatic preparation of the metabolites of food bioactive quercetin for bioavailability studies (2015–2017)
  • COST Action FA1403 – Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe, 2014–2018)

Publications

  • 71 original papers and reviews
  • 85 conference presentations
  • 5 textbooks
  • 1 patent

ResearcherID:   H-2515-2014, ORCID: 0000-0002-7714-5350, Scopus Author ID: 6602269085

Citation index (SCI, without autocitations): 1668

h-index: 23 (WOS All databases 27-Mar-20)

Selected recent publications

  1. Valentová, K., Havlík, J., Kosina, P., Papoušková, B., Jaimes, J. D., Káňová, K., Petrásková, L., Ulrichová, J. & Křen, V. (2020) Biotransformation of silymarin flavonolignans by human fecal microbiota. Metabolites, 10, 29. IF2018 3.303
  2. Viktorová, J., Dobiasová, S., Řehořová, K., Biedermann, D., Káňová, K., Šeborová, K., Václavíková, R., Valentová, K., Ruml, T., Křen, V. & Macek, T. (2019) Antioxidant, anti-inflammatory, and multidrug resistance modulation activity of silychristin derivatives. Antioxidants, 8, 303. IF2018 4.520
  3. Chambers, C.S.; Viktorová, J.; Řehořová, K.; Biedermann, D.; Turková, L.; Macek, T.; Křen, V.; Valentová, K. Defying multidrug resistance! Modulation of related transporters by flavonoids and flavonolignans. J. Agric. Food Chem. 2020, 10.1021/acs.jafc.9b00694. IF2018 3.571, 1 citation
  4. Valentová, K.*, Purchartová, K., Rydlová, L., Roubalová, L., Biedermann, D., Petrásková, L., Křenková, A.; Pelantová, H.; Holečková-Moravcová, V.; Tesařová, E.; Cvačka, J.; Vrba, J.; Ulrichová, J.; Křen, V. (2018) Sulfated metabolites of flavonolignans and 2,3-dehydroflavonolignans: Preparation and properties. J. Mol. Sci., 19, 2349. IF 4.183, 4 citations.
  5. Almeida, A. F.; Borge, G. I. A.; Piskula, M.; Tudose, A.; Tudoreanu, L.; Valentová, K.; Williamson, G.; Santos, C. N.*(2018) Review on the bioavailability of quercetin in humans with a focus on inter-individual variation Rev. Food Sci. Food Saf., 17, 714-731. IF 8.738, 14 citations

 

Last update: March 27, 2020