Doc. Ing. Kateřina Valentová, PhD.

Position:
Senior Scientist, Head of the Laboratory
Email:
kata.valentova@email.cz
katerina.valentova@biomed.cas.cz
Phone:
(+420) 296 442 509
Address:
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
Prague 4 – Krč
142 20
Czech Republic

Positions

  • 2021 (07)  Head of the Laboratory of Biotransformation
  • 2018 (07) Senior Researcher
  • 2017-2021 Deputy Head of Laboratory of Biotransformation
  • 2013 (09)- Researcher, Institute of Microbiology of the Czech Academy of Sciences
  • 2013 (01-08) Associate Professor
  • 2004-2012 Assistant Professor
  • 2003-2004 Research Assistant, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic

Education

  • 2011-2013 Associate Professor in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
  • 2000-2004 PhD in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
  • 1995-2000 in Biochemistry, Institute of Chemical Technology in Prague, CZ
  • 1990-1995 Bilingual high school (French – Czech) in Olomouc, CZ

Research Orientation

  • Metabolism and biotransformation of polyphenols
  • Biological activity of natural substances and plant extracts
  • Free radicals and their scavenging
  • Antioxidant and cytoprotective activity
  • Lipid peroxidation
  • Glucose metabolism
  • Hepatocytes, HUVEC
  • Angiogenesis

Experience

  • 1999 (1 month) Department of Clinical Biochemistry, Olomouc Teaching Hospital.
  • 1999 (3 months) Laboratory of Heterocycles and Glucides Chemistry, University Blaise Pascal, Clermont-Ferrand, France
  • 2001 (1 week) Ivax-Pharmaceuticals Co., Opava
  • 2002 (2 months) Laboratory of Molecular Biology and Physiology of the Vein, INSERM U541, Paris, France
  • 2003 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
  • 2004 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
  • 2005 (3 weeks) Laboratory of Molecular Toxicology, INSERM U490, Paris, France
  • 2006 (2 weeks) INSERM U775, Paris, France
  • 2012 (1 week) Université de Lille 2, France
  • 2013 (1 week) University of Colorado, USA
  • 2017 (1 week) ITQB NOVA, Oeiras, Portugal
  • 2018 (2 weeks) CNR, Milano, Italy

Courses

  • 1998–2000 Teaching of chemistry for high schools, Institute of Chemical Technology, in Prague, Czech Republic.
  • 2001 ACS Workshop, How to develop, Validate and Troubleshoot GS & HPLC Methods.
  • 2002 Chemistry and Biochemistry of Natural Compounds, Czech Academy of Science.
  • 2003 Good Research Practice in Biomedicine, Biological and Veterinary Sciences, international I-workshop for Ph.D. students.

Membership

  • 2000 Czech Chemical Society
  • 2006 Phytochemical Society of Europe
  • 2006 Czech Society for Probiotics and Prebiotics

Awards

  • 2003 Pharmacy Price, Aventis and French Embassy in Prague
  • 2003, 2005, 2008 Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication

Languages

  • French
  • English

Projects

  • GA23-04654S: Chemoenzymatic preparation and biological activity of metabolites of food polyphenols (2023-2025)
  • GA23-04655S: Role of prenylation and glycosylation patterns in antiinflammatory activity and metabolism of natural phenolic compounds (2023-2025)
  • NU21-02-00135: Cardiovascular effects of flavonoid metabolites and the influence of metabolic risk factors (2021-2024)
  • GA21-00551S: Metabolites and other derivatives of polyphenols – chemoenzymatic preparation and biological activity (2021-2023)
  • LTC20070: Natural polyphenolic compounds for adjunct tumor treatment combined with MDR inhibition (2020-2022)
  • GA18-00132S: Inter-individual variability in the metabolism of silymarin flavonolignans in humans (2018-2021)
  • GA18-00121S: The role of optically pure flavonolignans in cardiovascular effects of silymarin (2018-2021)
  • COST CA17104 – New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM, 2018-2022)
  • LTC19039: Gastrointestinal transformations of polyphenolic drugs (2019-2021)
  • COST Action CA16205 – European network on understanding gastrointestinal absorption-related processes (UNGAP, 2017-21)
  • GA15–03037S – Dehydro-derivatives of the silymarin flavonolignans: metabolism and biological activity (2015–2017)
  • LTC18003: Metabolism of silymarin flavonolignans in aging population (2018-2021)
  • COST Action CA16112: Personalized Nutrition in aging society: redox control of major age-related diseases (NutRedOx, 2017–2021)
  • LD15082 – Chemoenzymatic preparation of the metabolites of food bioactive quercetin for bioavailability studies (2015–2017)
  • COST Action FA1403 – Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe, 2014–2018)

Publications

  • 79 original papers and reviews
  • 85 conference presentations
  • 5 textbooks
  • 1 patent

ResearcherID:   H-2515-2014, ORCID: 0000-0002-7714-5350, Scopus Author ID: 6602269085, vedidk: 3973654

Citation index (SCI, without autocitations): 2341

h-index: 26 (WOS All databases 20/09/21)

Selected recent publications

  • Michael Kotík, Natalia Kulik, Kateřina Valentová: Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry. Journal of Agricultural and Food Chemistry, 71 (41), 14890-14910 (2023). 
  • Orsolya Balázs, Ágnes Dombi, Balázs Z. Zsidó, Csaba Hetényi, Kateřina Valentová, Róbert G. Vida, Miklós Poór: Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated metabolites. Biomedicine & Pharmacotherapy, 167 (November 2023), 115548: 1-10 (2023). 
  • Karin Chytilová, Adéla Galandáková, Kateřina Valentová, Peter Tvrdý: Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction. Biomedical Papers, 167 (2), 131-138 (2023). 
  • Kateřina Valentová: Editorial: Biotransformation of Natural Products and Phytochemicals: Metabolites, Their Preparation and Properties. International Journal of Molecular Sciences, 24 (9), 8030: 1-3 (2023). 
  • Hana Kaci, Slávka Bodnárová, Eszter Fliszár-Nyúl, Beáta Lemli, Helena Pelantová, Kateřina Valentová, Éva Bakos, Csilla Özvegy-Laczka, Miklós Poór: Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters. Biomedicine & Pharmacotherapy, 157, 114078:1-12 (2023). 
  • Kateřina Lněničková, Jiří Vrba, Pavel Kosina, Barbora Papoušková, Chahrazed Mekadim, Jakub Mrázek, Milan Sova, Eliška Sovová, Kateřina Valentová, Vladimír Křen, Pavla Kouřilová, Jana Vrbková, Jitka Ulrichová: Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study. Journal of Functional Foods, 100, 105391:1-16 (2023). 
  • Martina Hurtová, David Biedermann, Zuzana Osifová, Josef Cvačka, Kateřina Valentová, Vladimír Křen: Preparation of Synthetic and Natural Derivatives of Flavonoids Using Suzuki-Miyaura Cross-Coupling Reaction. Molecules, 27, 3, 967:1-16 (2022). 
  • Kateřina Holasová, Bára Křížskovská, Lan Hoang, Simona Dobiasová, Jan Lipov, Tomáš Macek, Vladimír Křen, Kateřina Valentová, Tomáš Ruml, Jitka Viktorová: Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureus. Biomedicine & Pharmacoteraphy, 149, 112806:1-14 (2022). 
  • Lucie Petrásková, Kristýna Káňová, Katerina Brodsky, Anastasiia Hetman, Barbora Petránková, Helena Pelantová, Vladimír Křen, Kateřina Valentová: Sulfated Phenolic Substances: Preparation and Optimized HPLC Analysis. International Journal of Molecular Sciences, 23 (10), 5743:1-18 (2022). 
  • Marcel Hrubša, Václav Tvrdý, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka: Interaction of Flavonoids with Zinc and Zinc-Containing Enzymes. Journal of Agricultural and Food Chemistry, 70 (20), 6134-6144 (2022). 
  • Vladimír Křen, Kateřina Valentová: Silybin and its congeners: from traditional medicine to molecular effects. Natural Product Reports, 39 (6), 1264-1281 (2022). 
  • Katerina Brodsky, Kristýna Káňová, Dorota Konvalinková, Kristýna Slámová, Helena Pelantová, Kateřina Valentová, Pavla Bojarová, Vladimír Křen, Lucie Petrásková: Bacterial Aryl Sulfotransferases in Selective and Sustainable Sulfation of Biologically Active Compounds using Novel Sulfate Donors. ChemSusChem, 15 (18), e202201253: 1-9 (2022). 
  • Martina Hurtová, Kristýna Káňová, Simona Dobiasová, Kateřina Holasová, Denisa Čáková, Lan Hoang, David Biedermann, Marek Kuzma, Josef Cvačka, Vladimír Křen, Jitka Viktorová, Kateřina Valentová: Selectively Halogenated Flavonolignans – Preparation and Antibacterial Activity. International Journal of Molecular Sciences, 23 (23), 15121: 1-18 (2022). 
  • Viola Kolaříková, Katerina Brodsky, Lucie Petrásková, Helena Pelantová, Josef Cvačka, Libor Havlíček, Vladimír Křen, Kateřina Valentová: Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis. International Journal of Molecular Sciences, 23 (23), 15171: 1-16 (2022). 
  • Biedermann David, Hurtová Martina, Biedermannová Lada, Valentová Kateřina, Křen Vladimír: Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper Mol. Recognit. e2812 (2019). Journal of Molecular Recognition, 34 (7), 2888 (2021).
  • Vinarov Zahari, Abrahamsson Bertil, Artursson Per, Batchelor Hannah, Berben Philippe, Valentová Kateřina, Patrick Augustijns, et al.: Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network. Advanced Drug Delivery Reviews, 171, 289-331 (2021). 
  • Faisal Zelma, Mohos Violetta, Fliszár-Nyúl Eszter, Valentová Kateřina, Káňová Kristýna, Lemli Beáta, Kunsági-Máté Sándor, Poór Miklós: Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9, 2C19, 2D6, and 3A4) enzymes. Biomedicine and Pharmacotherapy, 138, 111459 1-10 (2021).
  • Low Dorrain Yanwen, Micheau Pierre, Koistinen Mikael Ville, Hanhineva Kati, Valentová Kateřina, Petrásková Lucie, et a..: Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds. Food Chemistry, 357, 129757 1-10 (2021). 
  • Lomozová Zuzana, Tvrdý Václav, Hrubša Marcel, Catapano Maria Carmen, Macáková Kateřina, Biedermann David, Kučera Radim, Křen Vladimír, Mladěnka Přemysl, Valentová Kateřina: Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo. Antioxidants, 10 (5), 679, 1-17 (2021). 
  • Václav Tvrdý, Jana Pourová, Eduard Jirkovský, Vladimír Křen, Kateřina Valentová, Přemysl Mladěnka: Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin. Medicinal Research Reviews, 41 (4), 2195-2246 (2021). 
  • David Biedermann, Martina Hurtová, Oldřich Benada, Kateřina Valentová, Lada Biedermannová, Vladimír Křen: Continuous Diastereomeric Kinetic Resolution – Silybins A and B. Catalysts, 11 (9), 1106, 1-13 (2021). 
  • Václav Tvrdý, Marcel Hrubša, Eduard Jirkovský, David Biedermann, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka: Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol Dehydrogenase. Nutrients, 13 (12), 4238: 1-22 (2021).
  • Cláudia Nunes dos Santos, Regina Meneyes, Diogo Carregosa, Kateřina Valentová, Alexandre Foito, Gordon McDougall, Derek Stewart: Chapter 5 – Flavonols and Flavones. Dietary Polyphenols: Metabolism and Health Effects, editor: Tomás-Barberán, Francisco A . / González-Sarrías, Antonio / García-Villalba, Rocío, John Wiley and Sons, ISBN 978-1-119-56372-3, Hoboken, New Jersey, USA, 163-198 (online:2020, print:2021). 
  • Petrásková Lucie, Káňová Kristýna, Biedermann David, Křen Vladimír, Valentová Kateřina: Simple and Rapid HPLC Separation and Quantification of Flavonoid, Flavonolignans, and 2,3-Dehydroflavonolignans in Silymarin. Foods, 9 (2), 116:1-14 (2020). 
  • Valentová Kateřina, Havlík Jaroslav, Kosina Pavel, Papoušková Barbora, Jaimes José Diógenes, Káňová Kristýna, Petrásková Lucie, Ulrichová Jitka, Křen Vladimír: Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota. Metabolites, 10 (1), 29:1-16 (2020). 
  • Chambers S. Christopher, Viktorová Jitka, Řehořová Kateřina, Biedermann David, Turková Lucie, Macek Tomáš, Křen Vladimír, Valentová Kateřina: Defying Multidrug Resistance! Modulation of related Transporters by Flavonoids and Flavonolignans. Journal of Agricultural and Food Chemistry, 68 (7), 1763-1779 (2020). 
  • Simona Dobiasová, Kateřina Řehořová, Denisa Kučerová, David Biedermann, Kristýna Káňová, Lucie Petrásková, Kamila Koucká, Radka Václavíková, Kateřina Valentová, Tomáš Ruml, Tomáš Macek, Vladimír Křen, Jitka Viktorová: Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-inflammatory Potential. Antioxidants, 9 (5), 455:1-25 (2020). 
  • Jiří Vrba, Barbora Papoušková, Pavel Kosina, Kateřina Lněničková, Kateřina Valentová, Jitka Ulrichová: Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin. Metabolites, 10 (8), 329: 1-13 (2020). 
  • Kateřina Valentová: Editorial: Cytoprotective Activity of Natural and Synthetic Antioxidants. Antioxidants, 9 (8), 713: 1-4 (2020). 
  • Kristýna Káňová, Lucie Petrásková, Helena Pelantová, Zuzana Rybková, Kateřina Malachová, Josef Cvačka, Vladimír Křen, Kateřina Valentová: Sulfated Metabolites of Luteolin, Myricetin, and Ampelopsin: Chemoenzymatic Preparation and Biophysical Properties. Journal of Agricultural and Food Chemistry, 68 (40), 11197-11206 (2020). 
  • Biedermann David, Moravcová Veronika, Valentová Kateřina, Kuzma Marek, Petrásková Lucie, Císařová Ivana, Křen Vladimír: Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative. Phytochemistry Letters, 30, 14-20 (2019). 
  • Šuk Jakub, Jašprová Jana, Biedermann David, Petrásková Lucie, Valentová Kateřina, Křen Vladimír, Muchová Lucie, Vítek Libor: Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice. Oxidative Medicine and Cellular Longevity, Volume 2019, Article ID 6026902, 1-12 (2019). 
  • De Bruyne Tess, Steenput Bieke, Roth Lynn, De Meyer R.Y.Guido, Nunes dos Santos Claudia, Valentová Kateřina, Dambrova Maija, Hermans Nina: Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism. Nutrients, 11 (3), 578:1-43 (2019).
  • Koziolek Mirko, Alcaro Stefano, Augustijns Patrick, Basit W. Abdul, Grimm Michael, Hens Bart, Valentová Kateřina, et all., Maura Corsetti: The mechanism of pharmacokinetic food-drug interactions – A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences, 134, 31-59 (2019). 
  • Valentová Kateřina, Biedermann David, Křen Vladimír: 2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases. Proceedings, 11 (1), 21:1-4 (2019). 
  • Bassanini Ivan, Kapešová Jana, Petrásková Lucie, Pelantová Helena, Markošová Kristína, Rebroš Martin, Valentová Kateřina, Kotík Michael, Káňová Kristýna, Bojarová Pavla, Cvačka Josef, Turková Lucie, Ferrandi E. Erica, Bayout Ikram, Riva Sergio, Křen Vladimír: Glycosidase-Catalyzed Synthesis of Glycosyl Esters and Phenolic Glycosides of Aromatic Acids. Advanced Synthesis and Catalysis, 361 (11), 2627-2637 (2019). 
  • Begines Paloma, Biedermann David, Valentová Kateřina, Petrásková Lucie, Pelantová Helena, Maya Inés, Fernández-Bolaños G. José, Křen Vladimír: Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol, Tyrosol, and Acetylated Derivatives. Journal of Agricultural and Food Chemistry, 67 (26), 7281-7288 (2019). 
  • Chambers S. Christopher, Biedermann David, Valentová Kateřina, Petrásková Lucie, Viktorová Jitka, Kuzma Marek, Křen Vladimír: Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties. Antioxidants, 8 (7), 236:1-12 (2019). 
  • Viktorová Jitka, Dobiášová Simona, Řehořová Kateřina, Biedermann David, Káňová Kristýna, Šeborová Karolína, Václavíková Radka, Valentová Kateřina, Ruml Tomáš, Křen Vladimír, Macek Tomáš: Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Activity of Silychristin Derivatives. Antioxidants, 8 (8), 303:1-19 (2019). 
  • Pourová Jana, Applová Lenka, Macáková Kateřina, Vopršalová Marie, Migkos Thomas, Bentanachs Roger, Biedermann David, Petrásková Lucie, Tvrdý Václav, Hrubša Marcel, Karlíčková Jana, Křen Vladimír, Valentová Kateřina, Mladěnka Přemysl: The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo. Nutrients, 11 (10), 2286: 1-16 (2019). 
  • Vrba J., Papoušková B., Roubalová L., Zatloukalová M., Biedermann D., Křen V., Valentová K., Ulrichová J., Vacek J.: Metabolism of flavonolignans in human hepatocytes. Journal of Pharmaceutical and Biomedical Analysis, 152, 94-101 (2018). 
  • Almeida A.Filipa, Borge A. Grethe Iren, Piskula Mariusz, Tudose Adriana, Tudoreanu Liliana, Valentová Kateřina, Williamson Gary, Santos N. Cláudia: Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation. Comprehensive Reviews in Food Science and Food Safety, 17 (3), 714-731 (2018). 
  • Slámová Kristýna, Kapešová Jana, Valentová Kateřina: „Sweet Flavonoids“: Glycosidase-Catalyzed Modifications. International Journal of Molecular Sciences, 19 (7), 2126 (1-19) (2018). 
  • Valentová Kateřina, Purchartová Kateřina, Rydlová Lenka, Roubalová Lenka, Biedermann David, Petrásková Lucie, Křenková Alena, Pelantová Helena, Holečková-Moravcová Veronika, Tesařová Eva, Cvačka Josef, Vrba Jiří, Ulrichová Jitka, Křen Vladimír: Sulfated Metabolites of Flavonolignans and 2,3-Dehydroflavonolignans: Preparation and Properties. International Journal of Molecular Sciences, 19 (8), 2349 (1-17) (2018). 
  • Koistinen Ville Mikael, Da Silva Andreia Bento, Abrankó László, Low Dorrain, Villalba Rocio Garcia, Barberán Francisco Tomás, Landberg Rikard, Savolainen Otto, Alvarez-Acero Inmaculada, De Pascual-Teresa Sonia, Van Poucke Christof, Almeida Conceicao, Petrásková Lucie, Valentová Kateřina, Durand Stephanie, Wiczkowski Wieslaw, et.al.: Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics. Metabolites, 8 (3), 46 (1-17) (2018). 
  • Křen V., Valentová K.: Isoquercetin enzymatic production: A true story. Letter to Editor. Molecular Catalysis, 458 (part A), 112-114 (2018). 
  • Tvrdý Václav, Catapano Maria Carmen, Rawlik Tomasz, Karlíčková Jana, Biedermann David, Křen Vladimír, Mladěnka Přemysl, Valentová Kateřina: Interaction of isolated silymarin flavonolignans with iron and copper. Journal of Inorganic Biochemistry, 189 (December 2018), 115-123 (2018). 
  • Vavříková E., Křen V., Ježová-Kalachová Ľ., Biler M., Chantemargue B., Pyszková M., Riva S., Kuzma M., Valentová K., Ulrichová J., Vrba J., Trouillas P., Vacek J.: Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization. European Journal of Medicinal Chemistry, 127, 263-274 (2017). 
  • Karas D., Ulrichová J., Valentová K.: Galloylation of polyphenols alters their biological activity. Food and Chemical Toxicology, 105, 223-240 (2017). 
  • Heřmánková-Vavříková E., Křenková A., Petrásková L., Chambers C. S., Zápal J., Kuzma M., Valentová K., Křen V.: Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues. International Journal of Molecular Sciences, 18 (5), 1074 (1-14) (2017). 
  • Egea J., Valentová K., et al.: European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology, 13, 94-162 (2017).
  • Chambers S.C., Holečková V., Petrásková L., Biedermann D., Valentová K., Buchta M., Křen V.: The silymarin composition… and why does it matter??? Food Research International, 100 (3), 339-353 (2017). 
  • Valentová K., Káňová K., Di Meo F., Pelantová H., Chambers S.C., Rydlová L., Petrásková L., Křenková A., Cvačka J., Trouillas P., Křen V.: Chemoenzymatic Preparation and Biophysical Properties of Sulfated Quercetin Metabolites. International Journal of Molecular Sciences, 18 (11), 2231 (2017). 
  • Biler M., Biedermann D., Valentová K., Křen V., Kubala M.: Quercetin and its analogues: optical and acido-basic properties. Physical Chemistry Chemical Physics, 19 (39), 26870-26879 (2017). 
  • Catapano M.C., Tvrdý V., Karlíčková J., Migkos T., Valentová K., Křen V., Mladěnka: The Stoichiometry of Isoquercitrin Complex with Iron or Copper Is Highly Dependent on Experimental Conditions. Nutrients, 9 (11), 1193 (2017). 
  • Tilley C., Deep G., Agarwal C., Wempe F.M., Biedermann D., Valentová K., Křen V., Agarwal R.: Silibinin and Its 2,3-Dehydro-Derivative Inhibit Basal Cell Carcinoma Growth via Suppression of Mitogenic Signaling and Transcription Factors Activation. Molecular Carcinogenesis, 55 (1), 3-14 (2016). 
  • Pyszková M., Biler M., Biedermann D., Valentová K., Kuzma M., Vrba J., Ulrichová J., Sokolová R., Mojovic M., Popovic-Bijelic A., Kubala M., Trouillas P., Křen V., Vacek J.: Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. Free Radical Biology and Medicine, 90, 114-125 (2016). 
  • Valentová K., Šíma P., Rybková Z., Křížan J., Malachová K., Křen V.: (Anti)mutagenic and immunomodulatory properties of quercetin glycosides. Journal of the Science of Food and Agriculture, 96 (5), 1492-1499 (2016).
  • Karas D., Gažák R., Valentová K., Chambers S.C., Pivodová V., Biedermann D., Křenková A., Oborná I., Kuzma M., Cvačka J., Ulrichová J., Křen V.: Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells. Journal of Natural Products, 79 (4), 812-820 (2016). 
  • Vavříková E., Langschwager F., Ježová-Kalachová Ľ., Křenková A., Mikulová B., Kuzma M., Křen V., Valentová K.: Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties. International Journal of Molecular Sciences, 17 (6), 899, 1-12 (2016). 
  • Pivodová V., Zahler S., Karas D., Valentová K., Ulrichová J.: In vitro study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis. Pharmazie, 71, 478-483 (2016).
  • Biedermann D., Buchta M., Holečková V., Sedlák D., Valentová K., Cvačka J., Bednárová L., Křenková A., Kuzma M., Škuta C., Peikerová Ž., Bartůněk P., Křen V.: Silychristin: Skeletal Alterations and Biological Activities. Journal of Natural Products, 79 (12), 3086-3092 (2016). 
  • Purchartová K., Valentová K., Pelantová H., Marhol P., Cvačka J., Havlíček L., Křenková A., Vavříková E., Biedermann D., Chambers S.C., Křen V.: Prokaryotic and Eukaryotic Aryl Sulfotransferases: Sulfation of Quercetin and Its Derivatives. ChemCatChem, 7(19), 3152-3162 (2015). 
  • Chambers S.C., Valentová K., Křen V.: „Non-Taxifolin“ Derived Flavonolignans: Phytochemistry and Biology. Current Pharmaceutical Design, 21 (38), 5489-5500 (2015).
  • Vavříková E., Vacek J., Valentová K., Marhol P., Ulrichová J., Kuzma M., Křen V.: Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers. Molecules, 19 (4), 4115-4134 (2014). 
  • Valentová K., Vrba J., Bancířová M., Ulrichová J., Křen V.: Isoquercitrin: Pharmacology, toxikology, and metabolism. Food and Chemical Toxicology, 68, 267-282 (2014). 
  • Gavezzotti P., Vavříková E., Valentová K., Fronza G., Kudanga T., Kuzma M., Riva S., Biedermann D., Křen V.: Enzymatic oxidative dimerization of silymarin flavonolignans. Journal of Molecular Catalysis B: Enzymatic, 109, 24-30 (2014). 

 

 

 

Last update: October 3, 2023