Doc. Ing. Kateřina Valentová, PhD.

Position:
Senior Scientist, Head of the Laboratory
Email:
kata.valentova@email.cz
katerina.valentova@biomed.cas.cz
Phone:
(+420) 296 442 509
Address:
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
Prague 4 – Krč
142 20
Czech Republic

Positions

  • 2021 (07)  Head of the Laboratory of Biotransformation
  • 2018 (07) Senior Researcher
  • 2017-2021 Deputy Head of Laboratory of Biotransformation
  • 2013 (09)- Researcher, Institute of Microbiology of the Czech Academy of Sciences
  • 2013 (01-08) Associate Professor
  • 2004-2012 Assistant Professor
  • 2003-2004 Research Assistant, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic

Education

  • 2011-2013 Associate Professor in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
  • 2000-2004 PhD in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
  • 1995-2000 in Biochemistry, Institute of Chemical Technology in Prague, CZ
  • 1990-1995 Bilingual high school (French – Czech) in Olomouc, CZ

Research Orientation

  • Metabolism and biotransformation of polyphenols
  • Biological activity of natural substances and plant extracts
  • Free radicals and their scavenging
  • Antioxidant and cytoprotective activity
  • Lipid peroxidation
  • Glucose metabolism
  • Hepatocytes, HUVEC
  • Angiogenesis

Experience

  • 1999 (1 month) Department of Clinical Biochemistry, Olomouc Teaching Hospital.
  • 1999 (3 months) Laboratory of Heterocycles and Glucides Chemistry, University Blaise Pascal, Clermont-Ferrand, France
  • 2001 (1 week) Ivax-Pharmaceuticals Co., Opava
  • 2002 (2 months) Laboratory of Molecular Biology and Physiology of the Vein, INSERM U541, Paris, France
  • 2003 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
  • 2004 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
  • 2005 (3 weeks) Laboratory of Molecular Toxicology, INSERM U490, Paris, France
  • 2006 (2 weeks) INSERM U775, Paris, France
  • 2012 (1 week) Université de Lille 2, France
  • 2013 (1 week) University of Colorado, USA
  • 2017 (1 week) ITQB NOVA, Oeiras, Portugal
  • 2018 (2 weeks) CNR, Milano, Italy

Courses

  • 1998–2000 Teaching of chemistry for high schools, Institute of Chemical Technology, in Prague, Czech Republic.
  • 2001 ACS Workshop, How to develop, Validate and Troubleshoot GS & HPLC Methods.
  • 2002 Chemistry and Biochemistry of Natural Compounds, Czech Academy of Science.
  • 2003 Good Research Practice in Biomedicine, Biological and Veterinary Sciences, international I-workshop for Ph.D. students.

Membership

  • 2000 Czech Chemical Society
  • 2006 Phytochemical Society of Europe
  • 2006 Czech Society for Probiotics and Prebiotics

Awards

  • 2003 Pharmacy Price, Aventis and French Embassy in Prague
  • 2003, 2005, 2008 Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication

Languages

  • French
  • English

Projects

  • NU21-02-00135: Cardiovascular effects of flavonoid metabolites and the influence of metabolic risk factors 
  • GA21-00551S: Metabolites and other derivatives of polyphenols – chemoenzymatic preparation and biological activity
  • LTC20070: Natural polyphenolic compounds for adjunct tumor treatment combined with MDR
    inhibition
  • GA18-00132S: Inter-individual variability in the metabolism of silymarin flavonolignans in humans (2018-2021)
  • GA18-00121S: The role of optically pure flavonolignans in cardiovascular effects of silymarin (2018-2021)
  • COST CA17104 – New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM, 2018-2022)
  • LTC19039: Gastrointestinal transformations of polyphenolic drugs (2019-2021)
  • COST Action CA16205 – European network on understanding gastrointestinal absorption-related processes (UNGAP, 2017-21)
  • GA15–03037S – Dehydro-derivatives of the silymarin flavonolignans: metabolism and biological activity (2015–2017)
  • LTC18003: Metabolism of silymarin flavonolignans in aging population (2018-2021)
  • COST Action CA16112: Personalized Nutrition in aging society: redox control of major age-related diseases (NutRedOx, 2017–2021)
  • LD15082 – Chemoenzymatic preparation of the metabolites of food bioactive quercetin for bioavailability studies (2015–2017)
  • COST Action FA1403 – Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe, 2014–2018)

Publications

  • 79 original papers and reviews
  • 85 conference presentations
  • 5 textbooks
  • 1 patent

ResearcherID:   H-2515-2014, ORCID: 0000-0002-7714-5350, Scopus Author ID: 6602269085, vedidk: 3973654

Citation index (SCI, without autocitations): 2341

h-index: 26 (WOS All databases 20/09/21)

Selected recent publications

  1. Lomozová Z, Tvrdý V, Hrubša M, Catapano MC, Macáková K, Biedermann D, Kučera R, Křen V, Mladěnka P and Valentová K (2021) Dehydroflavonolignans from silymarin potentiate transition metal toxicity in vitro but are protective for isolated erythrocytes ex vivo. Antioxidants, 10, 679.
  2. Káňová K, Petrásková L, Pelantová H, Rybková Z, Malachová K, Cvačka J, Křen V and Valentová K (2020) Sulfated metabolites of luteolin, myricetin, and ampelopsin: Chemoenzymatic preparation and biophysical properties. J Agr Food Chem, 68, 11197-11206. IF2019192
  3. Valentová, K., Havlík, J., Kosina, P., Papoušková, B., Jaimes, J. D., Káňová, K., Petrásková, L., Ulrichová, J. & Křen, V. (2020) Biotransformation of silymarin flavonolignans by human fecal microbiota. Metabolites, 10, 29. IF2018 3.303, 4 cit.
  4. Valentová, K.*, Purchartová, K., Rydlová, L., Roubalová, L., Biedermann, D., Petrásková, L., Křenková, A.; Pelantová, H.; Holečková-Moravcová, V.; Tesařová, E.; Cvačka, J.; Vrba, J.; Ulrichová, J.; Křen, V. (2018) Sulfated metabolites of flavonolignans and 2,3-dehydroflavonolignans: Preparation and properties. J. Mol. Sci., 19, 2349. IF 4.183, 9 cit.
  5. Almeida, A. F.; Borge, G. I. A.; Piskula, M.; Tudose, A.; Tudoreanu, L.; Valentová, K.; Williamson, G.; Santos, C. N.*(2018) Review on the bioavailability of quercetin in humans with a focus on inter-individual variation Rev. Food Sci. Food Saf., 17, 714-731. IF 8.738, 49 cit.

 

Last update: September 24, 2021