Position:

Senior Scientist, Deputy Head

Email:

kata.valentova@email.cz

katerina.valentova@biomed.cas.cz

Phone:

(+420) 296 442 509

Address:

Laboratory of Biotransformation

Institute of Microbiology of the Czech Academy of Sciences

Vídeňská 1083

Prague 4 – Krč

142 20

Czech Republic

Positions

• 2021-2024  Head of the Laboratory of Biotransformation
• 2018 – Senior Researcher
• 2017-2021, 2024- Deputy Head of the Laboratory of Biotransformation
• 2013 – Researcher, Institute of Microbiology of the Czech Academy of Sciences
• 2013   Associate Professor
• 2004-2012 Assistant Professor
• 2003-2004 Research Assistant, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic

Education

• 2011-2013 Associate Professor in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
• 2000-2004 PhD in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
• 1995-2000 in Biochemistry, Institute of Chemical Technology in Prague, CZ
• 1990-1995 Bilingual high school (French – Czech) in Olomouc, CZ

Research Orientation

• Metabolism and biotransformation of polyphenols
• Biological activity of natural and semi-synthetic phenolic compounds
• Antioxidant, anti-lipoperoxidant and cytoprotective activity
• Cell cultures, angiogenesis, clinical studies

In the last 10 years, K. Valentová and her coworkers studied less common and neglected constituents of silymarin (milk thistle fruit extract), silychristin, silydianin, 2,3-dehydroflavonolignans, hydnocarpins and their derivatives (https://doi.org/10.1016/j.freeradbiomed.2015.11.014, http://doi.org/10.3390/nu13124238, http://doi.org/10.3390/antiox10050679, http://doi.org/10.1016/j.phytol.2019.01.006, http://doi.org/10.1021/acs.jnatprod.6b00750, https://doi.org/10.1021/acsomega.4c04627) and their analyses (http://doi.org/10.3390/foods9020116, http://doi.org/10.3390/ijms23105743). Some of them were evaluated for their effects on the cardiovascular system (http://doi.org/10.3390/nu11102286) and their inhibitory activities toward multidrug resistance associated transporters (http://doi.org/10.3390/antiox9050455, http://doi.org/10.3390/antiox8080303). In addition, the metabolic fate of silymarin components in the human body was investigated ex vivo (liver microsomes, fecal microflora) and in vivo focusing on possible interindividual variation (http://doi.org/10.3390/metabo10080329, http://doi.org/10.3390/metabo10010029, http://doi.org/10.1111/1541-4337.12342, http://doi.org/10.1016/j.jpba.2018.01.048, http://doi.org/10.1016/j.jff.2022.105391, https://doi.org/10.1002/mnfr.202400500). To this end, tentative, mostly sulfated metabolites are prepared and their bioactivity is studied (http://doi.org/10.1021/acs.jafc.0c03997, http://doi.org/10.1021/acs.jafc.9b01065, http://doi.org/10.3390/ijms19082349, http://doi.org/10.3390/ijms18112231, http://doi.org/10.3390/ijms232315171, http://doi.org/10.1002/cssc.202201253, https://doi.org/10.1021/acs.jafc.4c06771).

Experience

• 1999 (1 month) Department of Clinical Biochemistry, Olomouc Teaching Hospital.
• 1999 (3 months) Laboratory of Heterocycles and Glucides Chemistry, University Blaise Pascal, Clermont-Ferrand, France
• 2001 (1 week) Ivax-Pharmaceuticals Co., Opava
• 2002 (2 months) Laboratory of Molecular Biology and Physiology of the Vein, INSERM U541, Paris, France
• 2003 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
• 2004 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
• 2005 (3 weeks) Laboratory of Molecular Toxicology, INSERM U490, Paris, France
• 2006 (2 weeks) INSERM U775, Paris, France
• 2012 (1 week) Université de Lille 2, France
• 2013 (1 week) University of Colorado, USA
• 2017 (1 week) ITQB NOVA, Oeiras, Portugal
• 2018 (2 weeks) CNR, Milano, Italy

Courses

• 1998–2000 Teaching of chemistry for high schools, Institute of Chemical Technology, in Prague, Czech Republic.
• 2001 ACS Workshop, How to develop, Validate and Troubleshoot GS & HPLC Methods.
• 2002 Chemistry and Biochemistry of Natural Compounds, Czech Academy of Science.
• 2003 Good Research Practice in Biomedicine, Biological and Veterinary Sciences, international I-workshop for Ph.D. students.

Membership

• 2000 Czech Chemical Society
• 2006 Phytochemical Society of Europe
• 2006 Czech Society for Probiotics and Prebiotics
• 2020 Groupe Polyphénols

Awards

• 2003 Pharmacy Price, Aventis and French Embassy in Prague
• 2003, 2005, 2008 Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication

Languages

• French (fluent)
• English (fluent)
• Italian, Spanish, Russian, German (basics)

Projects

• GAČR 25-15246S – Unknown and unexplored molecules and biological activities of silymarin (2025-2028, PI)
• LUC24068 – The role of polyphenol structure in the flavour of plant-based food (2024-2027, PI)
• CZ.02.01.01/00/22_008/0004597: Talking to Microbes – Understanding Microbial Interactions in the One Health Concept (INTER-MICRO)(2024-2028)
• GA23-04654S: Chemoenzymatic preparation and biological activity of metabolites of food polyphenols (2023-2025)
• GA23-04655S: Role of prenylation and glycosylation patterns in antiinflammatory activity and metabolism of natural phenolic compounds (2023-2025)
• NU21-02-00135: Cardiovascular effects of flavonoid metabolites and the influence of metabolic risk factors (2021-2024)
• GA21-00551S: Metabolites and other derivatives of polyphenols – chemoenzymatic preparation and biological activity (2021-2023)
• LTC20070: Natural polyphenolic compounds for adjunct tumor treatment combined with MDR inhibition (2020-2022)
• GA18-00132S: Inter-individual variability in the metabolism of silymarin flavonolignans in humans (2018-2021)
• GA18-00121S: The role of optically pure flavonolignans in cardiovascular effects of silymarin (2018-2021)
• COST CA17104 – New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM, 2018-2022)
• LTC19039: Gastrointestinal transformations of polyphenolic drugs (2019-2021)
• COST Action CA16205 – European network on understanding gastrointestinal absorption-related processes (UNGAP, 2017-21)
• GA15–03037S – Dehydro-derivatives of the silymarin flavonolignans: metabolism and biological activity (2015–2017)
• LTC18003: Metabolism of silymarin flavonolignans in aging population (2018-2021)
• COST Action CA16112: Personalized Nutrition in aging society: redox control of major age-related diseases (NutRedOx, 2017–2021)
• LD15082 – Chemoenzymatic preparation of the metabolites of food bioactive quercetin for bioavailability studies (2015–2017)
• COST Action FA1403 – Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe, 2014–2018)

Publications

• 102 original papers and reviews
• 131 conference presentations
• 5 textbooks
• 2 patents

ResearcherID:   H-2515-2014, ORCID: 0000-0002-7714-5350, Scopus Author ID: 6602269085, vedidk: 3973654

Citation index (SCI, without autocitations): 4,076

h-index: 33 (WOS All databases 6/02/25)

Selected recent publications

• Brodsky, K., Petránková, B., Petrásková, L., Pelantová, H., Křen, V., Valentová, K. & Bojarová, P. (2024) New bacterial aryl sulfotransferases: Effective tools for sulfation of polyphenols, Agric. Food Chem. 72, 22208-22216. . IF₂₀₂₃ 5.7, AIS 0.903, D1
• Tomisova K, Jarosova V, Marsik P, Bergo AM, Cinek O, Hlinakova L, Kloucek P, Janousek V, Valentová K and Havlik J (2024) Mutual interactions of silymarin and colon microbiota in healthy young and healthy elder subjects. Nutr. Food Res., 68, 2400500.
• Lněničková, K., Vrba, J., Kosina, P., Papoušková, B., Mekadim, C., Mrázek, J., Sova, M., Sovová, E., Valentová, K., Křen, V., Kouřilová, P., Vrbková, J. & Ulrichová, J. (2023) Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study, Funct. Food.. 100, 105391. IF₂₀₂₂ 3.8, AIS 0.64, Q1, 4 cit.
• Křen V and Valentová K (2022) Silybin and its congeners: from traditional medicine to molecular effects. Prod. Rep., 39, 1264-1281. IF 11.9, AIS 3.079, D1, 31 cit.
• Brodsky, K., Káňová, K., Konvalinková, D., Slámová, K., Pelantová, H., Valentová, K., Bojarová, P., Křen, V. & Petrásková, L. (2022) Bacterial aryl sulfotransferases in selective and sustainable sulfation of biologically active compounds using novel sulfate donors, 15, e202201253. IF 8.4, AIS 1.582, Q1, 4 cit

Commissions of Trust and Serving Scientific Community:

Membership:

• Expert advisory board of the program INTER-ACTION (2020 onwards) and INTER-INFORM (2016 onwards, Ministry of Education, Youth and Sports of the Czech Republic)
• Evaluation panel P306 (2020-2023) and P303 (2019-2020)
• Doctoral Study Board of Medical Chemistry and Clinical Biochemistry, Palacký University Olomouc

Reviewing grant proposals:

• HORIZON 2020 FET-OPEN, Ministry of Education, Youth and Sports of the Czech Republic
• Technology Agency of the Czech Republic

Peer reviewing manuscripts:

• Food Chem. Toxicol., Molecules, Int. J. Mol. Sci, Biomedicines, Crit. Rev. Food Sci. Nutr., Marine Drugs, Crit. Rev. Anal. Chem., Pathogens, Crit. Rev. Toxicol., Medicina, Cosmetics, Redox Biol., J. Sci. Food Agr., Int. J. Exp. Pathol., Antioxidants, Appl. Microbiol., Plant Foods Hum. Nutr., J. Agr. Food Chem., etc.  – 81 verified reviews, WOS

Conference organization:

• 4th International Conference on Food Bioactives & Health 2023, Prague (chair)

Last update: March 07, 2025