RNDr. David Biedermann, PhD.

Senior Scientist
(+420) 296 442 360
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
Praha 4 – Krč
142 20
Czech Republic

Educational Record

  • 2003: Combined B.S. and M. Sc. in Organic Chemistry, Charles University in Prague, Faculty of Science.
  • 2009: PhD in Organic Chemistry, Charles University in Prague, Faculty of Science.

Professional Appointments

  • 9.2003-1.2009: PhD student, Charles University in Prague, Prague. Research interest: Natural compounds, anticancer triterpenoids, quaternary ammonium salts of triterpenoids.
  • 9.2010-8.2011: Postdoc, Vienna University of Technology, Vienna, Austria, group of Prof. M. D. Mihovilovic. Research interest: Preparation of chiral lactones using whole – cell Baeyer-Villiger biooxidation.
  • 7.2008-present: Scientist, Academy of Sciences of the Czech Republic, Institute of Microbiology, v.v.i., Research interest: Natural compounds, biocatalysis, chemoenzymatic synthesis, chemistry of silybin.

Academic Stays

  • 2004-2005: Socrates/Erasmus scholarship at University of Glasgow, group of Prof. Pavel Kočovský (full academic year).
  • 9-10.2009: Short term scientific mission: Effect of silybin analogues on VEGF pre-mRNA splicing, Liége, Belgium.
  • 4.2010: Short term scientific mission: In silico conformational analysis of silybin stereomers, Limoges, France.

Language skills

  • English (fluent, FCE), German (beginner, A2), Russian (beginner)

Work skills

Organic synthesis, natural products, terpenes, flavonoids, alkaloids. NMR, MS, IR, HPLC, GC, GC-MS, LC-MS. Work with tissue cultures, sterile work, whole cell biotransformations, PCR, PC, driving licence B, Gaussian – capable of basic computational chemistry. Leadership and presentation skills, soft skills.


Total 69 papers in impacted journals, 3 patents.

Citations (without autocitations, WOS 10.12.2019): 1222

H-index: 18

  • Martina Hurtová, David Biedermann, Zuzana Osifová, Josef Cvačka, Kateřina Valentová, Vladimír Křen: Preparation of Synthetic and Natural Derivatives of Flavonoids Using Suzuki-Miyaura Cross-Coupling Reaction. Molecules, 27, 3, 967:1-16 (2022). IF 4,927 
  • Pavel Kosina, Alena Ryšavá, Jitka Vostálová, Barbora Papoušková, David Biedermann, Jitka Ulrichová, Alena Rajnochová Svobodová: Stability and ultraviolet A photostability of silymarin polyphenols and its consequences for practical use in dermatology. Journal of Photochemistry & Photobiology, A: Chemistry, 429, 113897:1-12 (2022). IF 5,141 
  • Martina Hurtová, Kristýna Káňová, Simona Dobiasová, Kateřina Holasová, Denisa Čáková, Lan Hoang, David Biedermann, Marek Kuzma, Josef Cvačka, Vladimír Křen, Jitka Viktorová, Kateřina Valentová: Selectively Halogenated Flavonolignans – Preparation and Antibacterial Activity. International Journal of Molecular Sciences, 23 (23), 15121: 1-18 (2022). IF 6,208
  • Václav Tvrdý, Marcel Hrubša, Eduard Jirkovský, David Biedermann, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka: Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol Dehydrogenase. Nutrients, 13 (12), 4238: 1-22 (2021). IF 5,719 
  • David Biedermann, Martina Hurtová, Oldřich Benada, Kateřina Valentová, Lada Biedermannová, Vladimír Křen: Continuous Diastereomeric Kinetic Resolution – Silybins A and B. Catalysts, 11 (9), 1106, 1-13 (2021). IF 4,146 
  • Lomozová Zuzana, Tvrdý Václav, Hrubša Marcel, Catapano Maria Carmen, Macáková Kateřina, Biedermann David, Kučera Radim, Křen Vladimír, Mladěnka Přemysl, Valentová Kateřina: Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo. Antioxidants, 10 (5), 679, 1-17 (2021). IF 6,312
  • Franková Jana, Juráňová Jana, Biedermann David, Ulrichová Jitka: Influence of silymarin components on keratinocytes and 3D reconstructed epidermis. Toxicology in Vitro, 74, 105162, 1-7 (2021). IF 3,500
  • Biedermann David, Hurtová Martina, Biedermannová Lada, Valentová Kateřina, Křen Vladimír: Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper Mol. Recognit. e2812 (2019). Journal of Molecular Recognition, 34 (7), 2888 (2021). IF 2,137
  • Petrásková Lucie, Káňová Kristýna, Biedermann David, Křen Vladimír, Valentová Kateřina: Simple and Rapid HPLC Separation and Quantification of Flavonoid, Flavonolignans, and 2,3-Dehydroflavonolignans in Silymarin. Foods, 9 (2), 116:1-14 (2020).  IF 3,011 
  • Chambers S. Christopher, Viktorová Jitka, Řehořová Kateřina, Biedermann David, Turková Lucie, Macek Tomáš, Křen Vladimír, Valentová Kateřina: Defying Multidrug Resistance! Modulation of related Transporters by Flavonoids and Flavonolignans. Journal of Agricultural and Food Chemistry, 68 (7), 1763-1779 (2020). IF 4,192
  • Ludmila Martínková, Romana Příhodová, Natalia Kulik, Helena Pelantová, Barbora Křístková, Lucie Petrásková, David Biedermann: Biocatalyzed Reactions towards Functional Food Components 4-Alkylcatechols and Their Analogues. Catalysts, 10 (9), 1077: 1-14 (2020). IF 3,520
  • Martina Hurtová, David Biedermann, Marek Kuzma, Vladimír Křen: Mild and Selective Method of Bromination of Flavonoids. Journal of Natural Products, 83 (11), 3324-3331 (2020). IF 3,782
  • Hrčková Gabriela, Kubašková Mačák Terézia, Reiterová Katarína, Biedermann David: Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection. Experimental Parasitology, 213, 107888:1-11 (2020). IF 1,690
  • Simona Dobiasová, Kateřina Řehořová, Denisa Kučerová, David Biedermann, Kristýna Káňová, Lucie Petrásková, Kamila Koucká, Radka Václavíková, Kateřina Valentová, Tomáš Ruml, Tomáš Macek, Vladimír Křen, Jitka Viktorová: Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-inflammatory Potential. Antioxidants, 9 (5), 455:1-25 (2020). IF 5,014
  • Juráňová Jana, Aury-Landas Juliette, Boumediene Karim, Baugé Catherine, Biedermann David, Ulrichová Jitka, Franková Jana: Modulation of Skin Inflammatory Response by Active Components of Silymarin. Molecules, 24 (1), 123 (1-18) (2019). IF 3,060
  • Kosina Pavel, Paloncýová Markéta, Rajnochová Svobodová Alena, Zálešák Bohumil, Biedermann David, Ulrichová Jitka, Vostálová Jitka: Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study. Molecules, 24 (1), 61 (1-20) (2019). IF 3,060
  • Šuk Jakub, Jašprová Jana, Biedermann David, Petrásková Lucie, Valentová Kateřina, Křen Vladimír, Muchová Lucie, Vítek Libor: Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice. Oxidative Medicine and Cellular Longevity, Volume 2019, Article ID 6026902, 1-12 (2019). IF 4,868
  • Biedermann David, Moravcová Veronika, Valentová Kateřina, Kuzma Marek, Petrásková Lucie, Císařová Ivana, Křen Vladimír: Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative. Phytochemistry Letters, 30, 14-20 (2019). IF 1,338
  • Vostálová Jitka, Tinková Eva, Biedermann David, Kosina Pavel, Ulrichová Jitka, Rajnochová Svobodová Alena: Skin Protective Activity of Silymarin and its Flavonolignans. Molecules, 24 (6), 1022 (1-12) (2019). IF 3,060 
  • Valentová Kateřina, Biedermann David, Křen Vladimír: 2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases. Proceedings, 11 (1), 21:1-4 (2019). 
  • Begines Paloma, Biedermann David, Valentová Kateřina, Petrásková Lucie, Pelantová Helena, Maya Inés, Fernández-Bolaños G. José, Křen Vladimír: Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol, Tyrosol, and Acetylated Derivatives. Journal of Agricultural and Food Chemistry, 67 (26), 7281-7288 (2019). IF 3,571
  • Chambers S. Christopher, Biedermann David, Valentová Kateřina, Petrásková Lucie, Viktorová Jitka, Kuzma Marek, Křen Vladimír: Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties. Antioxidants, 8 (7), 236:1-12 (2019). IF 4,520 
  • Viktorová Jitka, Dobiasová Simona, Řehořová Kateřina, Biedermann David, Káňová Kristýna, Šeborová Karolína, Václavíková Radka, Valentová Kateřina, Ruml Tomáš, Křen Vladimír, Macek Tomáš: Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Avtivity of Silychristin Derivatives. Antioxidants, 8 (8), 303:1-19 (2019). IF 4,520
  • Rajnochová Svobodová Alena, Gabrielová Eva, Ulrichová Jitka, Zálešák Bohumil, Biedermann David, Vostálová Jitka: A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts. Archives of Dermatological Research, 311 (6), 477-490 (2019). IF 2,309 
  • Pourová Jana, Applová Lenka, Macáková Kateřina, Vopršalová Marie, Migkos Thomas, Bentanachs Roger, Biedermann David, Petrásková Lucie, Tvrdý Václav, Hrubša Marcel, Karlíčková Jana, Křen Vladimír, Valentová Kateřina, Mladěnka Přemysl: The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo. Nutrients, 11 (10), 2286: 1-16 (2019). IF 4,171
  • Vrba J., Papoušková B., Roubalová L., Zatloukalová M., Biedermann D., Křen V., Valentová K., Ulrichová J., Vacek J.: Metabolism of flavonolignans in human hepatocytes. Journal of Pharmaceutical and Biomedical Analysis, 152, 94-101 (2018). IF 2,831
  • Valentová Kateřina, Purchartová Kateřina, Rydlová Lenka, Roubalová Lenka, Biedermann David, Petrásková Lucie, Křenková Alena, Pelantová Helena, Holečková-Moravcová Veronika, Tesařová Eva, Cvačka Josef, Vrba Jiří, Ulrichová Jitka, Křen Vladimír: Sulfated Metabolites of Flavonolignans and 2,3-Dehydroflavonolignans: Preparation and Properties. International Journal of Molecular Sciences, 19 (8), 2349 (1-17) (2018). IF 3,687
  • Tvrdý Václav, Catapano Maria Carmen, Rawlik Tomasz, Karlíčková Jana, Biedermann David, Křen Vladimír, Mladěnka Přemysl, Valentová Kateřina: Interaction of isolated silymarin flavonolignans with iron and copper. Journal of Inorganic Biochemistry, 189 (December 2018), 115-123 (2018). IF 3,063 
  • Sheehan A., Messer A.E., Papadaki M., Choudhry A., Křen V., Biedermann D., Blagg B., Khandelwal A., Marston S.B.: Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin. Frontiers in Physiology, 9, 243:1-12 (2018). IF 3,394 
  • Olías-Molero Ana Isabel, Jiménez-Antón María Dolorez, Biedermann David, Corral J. María, Alunda José María: In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and donovani. Molecules, 23 (7), 1560 (1-12) (2018). IF 3,098
  • Hrčková Gabriela, Kubašková Mačák Terézia, Benada Oldřich, Kofroňová Olga, Tůmová Lenka, Biedermann David: Differential Effects of the Flavonolignans Silybin, Silychristin and 2,3-Dehydrosilybin on Mesocestoides vogae Larvae (Cestoda) under Hypoxic and Aerobic In Vitro Conditions. Molecules, 23 (11), 2999 (1-19) (2018). IF 3,098
  • Biler M., Biedermann D., Valentová K., Křen V., Kubala M.: Quercetin and its analogues: optical and acido-basic properties. Physical Chemistry Chemical Physics, 19 (39), 26870-26879 (2017). IF 4,123
  • Filippopoulou K., Papaevgeniou N., Lefaki M., Paraskevopoulou A., Biedermann D., Křen V., Chondrogianni N.: 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radical Biology and Medicine, 103, 256-267 (2017). IF 5,606
  • Chambers S.C., Holečková V., Petrásková L., Biedermann D., Valentová K., Buchta M., Křen V.: The silymarin composition… and why does it matter??? Food Research International, 100 (3), 339-353 (2017). IF 3,086
  • Roubalová L., Dinkova-Kostova T. A., Biedermann D., Křen V., Ulrichová J., Vrba J.: Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P) H: quinone oxidoreductase 1 in Hepa1c1c7 cells. Fitoterapia, 119, 115-120 (2017). IF 2,698
  • Sokolová R., Kocábová J., Marhol P., Fiedler J., Biedermann D., Vacek J., Křen V.: Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral Study. The Journal of Physical Chemistry B, 121 (28), 6841-6846 (2017). IF 3,177 
  • Tilley C., Deep G., Agarwal C., Wempe F.M., Biedermann D., Valentová K., Křen V., Agarwal R.: Silibinin and Its 2,3-Dehydro-Derivative Inhibit Basal Cell Carcinoma Growth via Suppression of Mitogenic Signaling and Transcription Factors Activation. Molecular Carcinogenesis, 55 (1), 3-14 (2016). IF 4,722 
  • Svobodová Rajnochová A., Zálešák B., Biedermann D., Ulrichová J., Vostálová J.: Phototoxic potential of silymarin and its bioactive components. Jourmal of Photochemistry and Photobiology, B: Biology, 156, 61-68 (2016). IF 3,035
  • Roubalová L., Biedermann D., Papoušková B., Vacek J., Kuzma M., Křen V., Ulrichová J., Kostova-T.Dinkova A., Vrba J.: Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells. Chemico-Biological Interactions, 260, 58-66 (2016). IF 2,618 
  • Pyszková M., Biler M., Biedermann D., Valentová K., Kuzma M., Vrba J., Ulrichová J., Sokolová R., Mojovic M., Popovic-Bijelic A., Kubala M., Trouillas P., Křen V., Vacek J.: Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. Free Radical Biology and Medicine, 90, 114-125 (2016). IF 5,784 
  • Kubala M., Čechová P., Geletičová J., Biler M., Štenclová T., Trouillas P., Biedermann D.: Flavonolignans as a novel class of sodium pump inhibitors. Frontiers in Physiology, 7,115 (2016). IF 4,031
  • Karas D., Gažák R., Valentová K., Chambers S.C., Pivodová V., Biedermann D., Křenková A., Oborná I., Kuzma M., Cvačka J., Ulrichová J., Křen V.: Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells. Journal of Natural Products, 79 (4), 812-820 (2016). IF 3,662
  • Huang G., Schramm S., Heilmann J., Biedermann D., Křen V., Decker M.: Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins. Beilstein Journal of Organic Chemistry, 12, 662-669 (2016). IF 2,697 
  • Biler M., Trouillas P., Biedermann D., Křen V., Kubala M.: Tunable optical properties of silymarin flavonolignans. Jourmal of Photochemistry and Photobiology A: Chemistry, 328, 154-162 (2016). IF 2,477
  • Biedermann D., Buchta M., Holečková V., Sedlák D., Valentová K., Cvačka J., Bednárová L., Křenková A., Kuzma M., Škuta C., Peikerová Ž., Bartůněk P., Křen V.: Silychristin: Skeletal Alterations and Biological Activities. Journal of Natural Products, 79 (12), 3086-3092 (2016). IF 3,662 
  • Vavříková E., Gavezzotti P., Purchartová K., Fuksová K., Biedermann D., Kuzma M., Riva S., Křen V.: Regioselective Alcoholysis of Silychristin Acetates Catalyzed by Lipases. International Journal of Molecular Sciences, 16 (6), 11983-11995 (2015). IF 2,862
  • Purchartová K., Valentová K., Pelantová H., Marhol P., Cvačka J., Havlíček L., Křenková A., Vavříková E., Biedermann D., Chambers S.C., Křen V.: Prokaryotic and Eukaryotic Aryl Sulfotransferases: Sulfation of Quercetin and Its Derivatives. ChemCatChem, 7(19), 3152-3162 (2015). IF 4,556
  • Novotná M., Gažák R., Biedermann D., Di Meo F., Marhol P., Kuzma M., Bednárová L., Fuksová K., Trouillas P., Křen V.: cis-trans Isomerization of silybin A and B. Beilstein Journal of Organic Chemistry, 10, 1047-1063 (2014). IF 2,803
  • Křenek K., Marhol P., Peikerová Ž., Křen V., Biedermann D.: Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel. Food Research International, 65 (Part A), 115-120 (2014). IF 3,050
  • Biedermann D., Vavříková E., Cvak L., Křen V.: Chemistry of silybin. Natural Product Reports, 31(9), 1138-1157 (2014). IF 10,715
  • Gavezzotti P., Vavříková E., Valentová K., Fronza G., Kudanga T., Kuzma M., Riva S., Biedermann D., Křen V.: Enzymatic oxidative dimerization of silymarin flavonolignans. Journal of Molecular Catalysis B: Enzymatic, 109, 24-30 (2014). IF 2,745


Last update: March 15, 2023