Doc. Ing. Kateřina Valentová, PhD. : biotrans

Position:: Senior Scientist, Head of the Laboratory
Email:: kata.valentova@email.cz; katerina.valentova@biomed.cas.cz
Phone:: (+420) 296 442 509
Address:: Laboratory of Biotransformation; Institute of Microbiology of the Czech Academy of Sciences; Vídeňská 1083; Prague 4 – Krč; 142 20; Czech Republic

Positions

2021 (07) Head of the Laboratory of Biotransformation
2018 (07) Senior Researcher
2017-2021 Deputy Head of Laboratory of Biotransformation
2013 (09)- Researcher, Institute of Microbiology of the Czech Academy of Sciences
2013 (01-08) Associate Professor
2004-2012 Assistant Professor
2003-2004 Research Assistant, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic

2011-2013 Associate Professor in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
2000-2004 PhD in Medical Chemistry and Biochemistry, Palacký University, Olomouc, CZ
1995-2000 in Biochemistry, Institute of Chemical Technology in Prague, CZ
1990-1995 Bilingual high school (French – Czech) in Olomouc, CZ

1999 (1 month) Department of Clinical Biochemistry, Olomouc Teaching Hospital.
1999 (3 months) Laboratory of Heterocycles and Glucides Chemistry, University Blaise Pascal, Clermont-Ferrand, France
2001 (1 week) Ivax-Pharmaceuticals Co., Opava
2002 (2 months) Laboratory of Molecular Biology and Physiology of the Vein, INSERM U541, Paris, France
2003 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
2004 (2 weeks) Laboratory of Food Chemistry, National Institute of Chemistry, Slovenia
2005 (3 weeks) Laboratory of Molecular Toxicology, INSERM U490, Paris, France
2006 (2 weeks) INSERM U775, Paris, France
2012 (1 week) Université de Lille 2, France
2013 (1 week) University of Colorado, USA
2017 (1 week) ITQB NOVA, Oeiras, Portugal
2018 (2 weeks) CNR, Milano, Italy

1998–2000 Teaching of chemistry for high schools, Institute of Chemical Technology, in Prague, Czech Republic.
2001 ACS Workshop, How to develop, Validate and Troubleshoot GS & HPLC Methods.
2002 Chemistry and Biochemistry of Natural Compounds, Czech Academy of Science.
2003 Good Research Practice in Biomedicine, Biological and Veterinary Sciences, international I-workshop for Ph.D. students.

2003 Pharmacy Price, Aventis and French Embassy in Prague
2003, 2005, 2008 Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication

NU21-02-00135: Cardiovascular effects of flavonoid metabolites and the influence of metabolic risk factors
GA21-00551S: Metabolites and other derivatives of polyphenols – chemoenzymatic preparation and biological activity
LTC20070: Natural polyphenolic compounds for adjunct tumor treatment combined with MDR
inhibition
GA18-00132S: Inter-individual variability in the metabolism of silymarin flavonolignans in humans (2018-2021)
GA18-00121S: The role of optically pure flavonolignans in cardiovascular effects of silymarin (2018-2021)
COST CA17104 – New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM, 2018-2022)
LTC19039: Gastrointestinal transformations of polyphenolic drugs (2019-2021)
COST Action CA16205 – European network on understanding gastrointestinal absorption-related processes (UNGAP, 2017-21)
GA15–03037S – Dehydro-derivatives of the silymarin flavonolignans: metabolism and biological activity (2015–2017)
LTC18003: Metabolism of silymarin flavonolignans in aging population (2018-2021)
COST Action CA16112: Personalized Nutrition in aging society: redox control of major age-related diseases (NutRedOx, 2017–2021)
LD15082 – Chemoenzymatic preparation of the metabolites of food bioactive quercetin for bioavailability studies (2015–2017)
COST Action FA1403 – Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe, 2014–2018)

ResearcherID: H-2515-2014, ORCID: 0000-0002-7714-5350, Scopus Author ID: 6602269085, vedidk: 3973654

Citation index (SCI, without autocitations): 2341

h-index: 26 (WOS All databases 20/09/21)

Lomozová Z, Tvrdý V, Hrubša M, Catapano MC, Macáková K, Biedermann D, Kučera R, Křen V, Mladěnka P and Valentová K (2021) Dehydroflavonolignans from silymarin potentiate transition metal toxicity in vitro but are protective for isolated erythrocytes ex vivo. Antioxidants, 10, 679.
Káňová K, Petrásková L, Pelantová H, Rybková Z, Malachová K, Cvačka J, Křen V and Valentová K (2020) Sulfated metabolites of luteolin, myricetin, and ampelopsin: Chemoenzymatic preparation and biophysical properties. J Agr Food Chem, 68, 11197-11206. IF₂₀₁₉192
Valentová, K., Havlík, J., Kosina, P., Papoušková, B., Jaimes, J. D., Káňová, K., Petrásková, L., Ulrichová, J. & Křen, V. (2020) Biotransformation of silymarin flavonolignans by human fecal microbiota. Metabolites, 10, 29. IF₂₀₁₈3.303, 4 cit.
Valentová, K.*, Purchartová, K., Rydlová, L., Roubalová, L., Biedermann, D., Petrásková, L., Křenková, A.; Pelantová, H.; Holečková-Moravcová, V.; Tesařová, E.; Cvačka, J.; Vrba, J.; Ulrichová, J.; Křen, V. (2018) Sulfated metabolites of flavonolignans and 2,3-dehydroflavonolignans: Preparation and properties. J. Mol. Sci., 19, 2349. IF 4.183, 9 cit.
Almeida, A. F.; Borge, G. I. A.; Piskula, M.; Tudose, A.; Tudoreanu, L.; Valentová, K.; Williamson, G.; Santos, C. N.^*(2018) Review on the bioavailability of quercetin in humans with a focus on inter-individual variation Rev. Food Sci. Food Saf., 17, 714-731. IF 8.738, 49 cit.

Last update: September 24, 2021