Mgr. Jana Šmigová, Ph.D.

Position:
Scientific Staff
Email:
jana.smigova@mbu.cas.cz
Phone:
(+420) 296 442 405
Address:
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
Praha 4 – Krč
142 00
Czech Republic

Education

  • Ph.D. in Cell biology, First Faculty of Medicine, Charles University in Prague, Institute of Cellular Biology and Pathology (2012)

Dissertation thesis: Relationship between higher order chromatin structure and gene silencing. Polycomb bodies.

  • M.Sc. in Cytology, Faculty of Natural Sciences, Comenius University in Bratislava (2005)
  • B.Sc. in Biology, Faculty of Natural Sciences, Comenius University in Bratislava (2003)

Employment

  • 2020–2026 Department of Cell Biology, Faculty of Sciences, Charles University, BIOCEV
  • 2017–2019 Department of Molecular Biology, Umeå University, Umeå, Sweden
  • 2016–2005 Institute of Cellular Biology and Pathology, First Faculty of Medicine, Charles University in Prague, Czech Republic
  • 2009–2011 Department of Cell Biology, Institute of Physiology ASCR, v.v.i., Prague

International stays

  • Sept–Dec 2014 Human Biology and Bioimaging, Faculty of Biology, Ludwig-Maximilians Universität München, Munich, Germany
  • April 2013 Department of Cell and Developmental Biology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, USA
  • Feb–May 2008 School of Biochemistry, University of Bristol, Bristol, UK

Identifiers

ORCID:0000-0002-3152-5649

ResearcherID: O-9579-2017

Scopus Author ID: 25622803200

Publications

  • Sukanya B Jadhav, Michaela Vondrackova, Petra Potomova, Cristian Sandoval-Acuña, Jana Smigova, Kristyna Klanicova, Daniel Rosel, Jan Brabek, Jan Stursa, Lukas Werner, Jaroslav Truksa. NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation. Front Pharmacol, 2024 Jun 25:15:1422369. 2024
  • Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Šmigová J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Brábek J, Jakubek M, Neuzil J, Masarik M. Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. Biomed Pharmacother. 2022 Oct;154:113582.
  • Stemberkova-Hubackova S, Zobalova R, Dubisova M, Smigova J, Dvorakova S, Korinkova K, Ezrova Z, Endaya B, Blazkova K, Vlcak E, Brisudova P, Le DT, Juhas S, Rosel D, Daniela Kelemen C, Sovilj D, Vacurova E, Cajka T, Filimonenko V, Dong L, Andera L, Hozak P, Brabek J, Bielcikova Z, Stursa J, Werner L, Neuzil Simultaneous targeting of mitochondrial metabolism and immune checkpoints as a new strategy for renal cancer therapy. Clin Transl Med. 2022 Mar;12(3):e645.
  • Strnadová K, Pfeiferová L, Přikryl P, Dvořánková B, Vlčák E, Frýdlová J, Vokurka M, Novotný J, Šáchová J, Hradilová M, Brábek J, Šmigová J, Rösel D, Smetana K Jr, Kolář M, Lacina L. Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts. Histochem Cell Biol. 2022 Feb;157(2):153-172.
  • Farkaš R, Beňová-Liszeková D, Mentelová L, Mahmood S, Ďatková Z, Beňo M, Pečeňová L, Raška O, Šmigová J, Chase BA, Raška I, Mechler BM. Vacuole dynamics in the salivary glands of Drosophila melanogaster during prepupal development. Dev Growth Differ. 2015; 57(1):74-96.
  • Smigova J, Juda P, Krejci J, Raska I. Structural Basis of Polycomb bodies. Folia Biologica. 2014; 60:13-20.
  • Juda P, Smigova J, Kovacik L, Bartova E, Raska I. Ultrastructure of Cytoplasmic and Nuclear Inosine-5’-monophosphate Dehydrogenase 2 “Rods and Rings” Inclusions. J Histochem Cytochem. 2014; 62(10):739-50.
  • Farkaš R, Datková Z, Mentelová L, Löw P, Beňová-Liszeková D, Beňo M, Sass M, Rehulka P, Rehulková H, Raška O, Kováčik L, Smigová J, Raška I, Mechler BM. Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins. PLoS One. 2014;9(4):e94383.
  • Smigová J, Juda P, Bártová E, Raška I. Dynamics of Polycomb chromatin domains under conditions of increased molecular crowding. Biol Cell. 2013;105(11):519-34.
  • Šmigová J, Juda P, Cmarko D, Raška I. Fine structure of the „PcG body“ in human U-2 OS cells established by correlative light-electron microscopy. Nucleus 2011; 2(3):219-28.
  • Gancarcíková M, Zemanová Z, Brezinová J, Berková A, Vcelíková S, Smigová J, Michalová K. The role of telomeres and telomerase complex in haematological neoplasia: the length of telomeres as a marker of carcinogenesis and prognosis of disease. Prague Med Rep. 2010; 111(2):91-105.
  • Krejcí J, Uhlírová R, Galiová G, Kozubek S, Smigová J, Bártová E. Genome-wide reduction in H3K9 acetylation during human embryonic stem cell differentiation. J Cell Physiol. 2009; 219(3):677-87.
  • Cmarko D, Smigova J, Minichova L, Popov A. Nucleolus: the ribosome factory. Histol Histopathol. 2008; 23(10):1291-8.
  • Slamenova D, Sramkova M, Chalupa I, Smigova J, Kogan G. Reduction of genotoxic effects of N-nitrosomorpholine in human hepatoma cells and hamster lung cells by carboxymethyl chitin-glucan. 2008; 55(4):280-5.

 

Last update: May 18, 2026