- Position:
- Scientific Staff
- Email:
- michaela.hovorkova@biomed.cas.cz
- Phone:
- (+420) 296 442 360
- Address:
- Laboratory of Biotransformation
- Institute of Microbiology of the Czech Academy of Sciences
- Vídeňská 1083
- Praha 4 – Krč
- 142 20
- Czech Republic
Education
- 2020 – now: Ph.D. study: Charles University in Prague, Faculty of Natural Sciences, Microbiology, doctoral thesis “Fusion constructs of galectins with biomedical potential and their ligands“
- 2018 – 2020: Master study: Charles University in Prague, Faculty of Nature Sciences, Microbiology, master thesis “Engineering of microbial glycosidases for modifying substrate specificity“
- 2018: Graduation, Bc. (biochemistry) at Charles University in Prague, Faculty of Natural Sciences, bachelor thesis “Multivalent carbohydrate ligands of galectins”
- 2015: Graduation exam at Gymnasium Na Vítězné pláni, Prague
Employment
- 2/2018 – now: Institute of Microbiology of the Czech Academy of Sciences
- 8/2016: Institute of Microbiology of the Czech Academy of Sciences (work with laboratory mice)
- 8/2012: Institute of Rheumatology (questionnaire research)
Fields of Interest
- Microbiology, Biochemistry, Glycobiology, Glycochemistry, Molecular Genetics, PCR, Microbial Production, Carbohydrates, Galectins, Mutagenesis, Cell assays, Enzymatic Synthesis
Languages
- English: fluent, German: passive knowledge
Publications
9 publications, 73 citations, H-index: 6 (WOS, 09/24)
- Michaela Hovorková, Barbora Kaščáková, Lucie Petrásková, Petra Havlíčková, Jiří Nováček, Daniel Pinkas, Zdenko Gardian, Vladimír Křen, Pavla Bojarová, Ivana Kutá Smatanová: The variable structural flexibility of the Bacillus circulans β-galactosidase isoforms determines their unique functionalities. Structure, 32, 1-15 (2024).
- Vrbata, J. Červený, N. Kulik, M. Hovorková, S. Balogová, M. Vlachová, H. Pelantová, V. Křen, P. Bojarová: Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient. Bioorg. Chem., 2024, 145: 107231. (IF 5.1)
- Müllerová, M. Hovorková, T. Závodná, L. Červenková Šťastná, Al. Krupková, V. Hamala, K. Nováková, J. Topinka, P. Bojarová, T. Strašák: Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior. Biomacromolecules, 2023, 24, 11, 4705-4717. (IF: 6.2)
- Konvalinková, F. Dolníček, M. Hovorková, J. Červený, O. Kundrát, H. Pelantová, L. Petrásková, J. Cvačka, M. Faizulina, B. Varghese, P. Kovaříček, V. Křen, P. Lhoták, P. Bojarová: Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters. Org. Biomol. Chem., 2023. (IF 3.89)
- Hovorková, J. Červený, L. Bumba, H. Pelantová, J. Cvačka, V. Křen, O. Renaudet, D. Goyard, P. Bojarová. Advanced High-Affinity Glycocluster Ligands of Galectins. Bioorg. Chem., 2023, 131:106279. (IF 5.1)
- Nekvasilová, M. Hovorková, Z. Mészáros, L. Petrásková, H. Pelantová, V. Křen, K. Slámová, P. Bojarová. Engineered Glycosidases for the Synthesis of Analogs of Human Milk Oligosaccharides. Int. J. Mol. Sci., 2022, 23(8). (IF 6.208)
- Hovorková, N. Kulik, D. Konvalinková, L. Petrásková, V. Křen, P. Bojarová. Mutagenesis of catalytic nucleophile of β-galactosidase retains residual hydrolytic activity and affords a transgalactosidase. ChemCatChem, 2021, 13(21), 4532-4542. (IF 5.686)
- Kurfiřt, M. Dračínský, L. Červenková Šťastná, P. Cuřínová, V. Hamala, M. Hovorková, P. Bojarová, J. Karban. Selectively Deoxyfluorinated N-Acetyllactosamine Analogues as 19F NMR Probes to Study Carbohydrate-Galectin Interactions. Chem. Eur. J., 2021, 27(51), 13040-13051. (IF 4.857)
- Heine*, M. Hovorková*, M. Vlachová, M. Filipová, L. Bumba, O. Janoušková, M. Hubálek, J. Cvačka, L. Petrásková, H. Pelantová, V. Křen, L. Elling, P. Bojarová. Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3. Eur J Med Chem., 2021, 220: 113500. (IF 7.088)
- Bojarová, N. Kulik, M. Hovorková, K. Slámová, H. Pelantová, V. Křen. The β-N-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering. Molecules, 2019, 24(3): 599 (IF 3.098)
Last update: November 05, 2024