RNDr. David Biedermann, PhD.

Position:
Senior Scientist
Email:
biedermann@biomed.cas.cz
Phone:
(+420) 296 442 360
Address:
Laboratory of Biotransformation
Institute of Microbiology of the Czech Academy of Sciences
Vídeňská 1083
Praha 4 – Krč
142 20
Czech Republic

Educational Record

  • 2003: Combined B.S. and M. Sc. in Organic Chemistry, Charles University in Prague, Faculty of Science.
  • 2009: PhD in Organic Chemistry, Charles University in Prague, Faculty of Science.

Professional Appointments

  • 9.2003-1.2009: PhD student, Charles University in Prague, Prague. Research interest: Natural compounds, anticancer triterpenoids, quaternary ammonium salts of triterpenoids.
  • 9.2010-8.2011: Postdoc, Vienna University of Technology, Vienna, Austria, group of Prof. M. D. Mihovilovic. Research interest: Preparation of chiral lactones using whole – cell Baeyer-Villiger biooxidation.
  • 7.2008-present: Scientist, Academy of Sciences of the Czech Republic, Institute of Microbiology, v.v.i., Research interest: Natural compounds, biocatalysis, chemoenzymatic synthesis, chemistry of silybin.

Academic Stays

  • 2004-2005: Socrates/Erasmus scholarship at University of Glasgow, group of Prof. Pavel Kočovský (full academic year).
  • 9-10.2009: Short term scientific mission: Effect of silybin analogues on VEGF pre-mRNA splicing, Liége, Belgium.
  • 4.2010: Short term scientific mission: In silico conformational analysis of silybin stereomers, Limoges, France.

Language skills

  • English (fluent, FCE), German (beginner, A2), Russian (beginner)

Work skills

Organic synthesis, natural products, terpenes, flavonoids, alkaloids. NMR, MS, IR, HPLC, GC, GC-MS, LC-MS. Work with tissue cultures, sterile work, whole cell biotransformations, PCR, PC, driving licence B, Gaussian – capable of basic computational chemistry. Leadership and presentation skills, soft skills.

Publications

Total 69 papers in impacted journals, 3 patents.

Citations (without autocitations, WOS 10.12.2019): 1222

H-index: 18

 

  1. Novotná M., Gažák R., Biedermann D., Di Meo F., Marhol P., Kuzma M., Bednařová L., Fuksová K., Trouillas P., Křen V.: cis-trans Isomerization of silybins A and B. Beilstein, Org. Chem. 10, 1047-1063 (2014). IF2014: 2.76
  2. Křenek K., Marhol P., Peikerová Ž., Křen V., Biedermann D.*: Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel. Food Research International, 65, 115-120 (2014). IF2014: 2.81
  3. Biedermann D., Vavříková E., Cvak L., Křen V.: Chemistry of silybin. Prod. Rep. 31. 1138-1157 (2014) IF2014: 10.11
  4. Gavezzotti, P.; Vavrikova, E.; Valentova, K.; Fronza, G.; Kudanga, T.; Kuzma, M.; Riva, S.; Biedermann, D.; Kren, V., Enzymatic oxidative dimerization of silymarin flavonolignans. Journal of Molecular Catalysis B-Enzymatic 109, 24-30 (2014). IF2014: 2.13
  5. Vavrikova, E.; Gavezzotti, P.; Purchartova, K.; Fuksova, K.; Biedermann, D.; Kuzma, M.; Riva, S.; Kren, V., Regioselective alcoholysis of silychristin acetates catalyzed by lipases. International journal of molecular sciences 2015, 16, (6), 11983-95. IF2015: 3.26
  6. Purchartová, K.; Valentová, K.; Pelantová, H.; Marhol, P.; Cvačka, J.; Havlíček, L.; Křenková, A.; Vavříková, E.; Biedermann, D.; Chambers, C. S.; Křen, V., Prokaryotic and Eukaryotic Aryl Sulfotransferases: Sulfation of Quercetin and Its Derivatives. ChemCatChem 2015, 7, (19), 3152-3162. IF2015: 4.72
  7. Tilley, C.; Deep, G.; Agarwal, C.; Wempe, M. F.; Biedermann, D.; Valentova, K.; Kren, V.; Agarwal, R., Silibinin and Its 2,3-Dehydro-Derivative Inhibit Basal Cell Carcinoma Growth via Suppression of Mitogenic Signaling and Transcription Factors Activation. Molecular Carcinogenesis 2016, 55 (1), 3-14. IF2016: 4.19
  8. Svobodova, A. R.; Zalesak, B.; Biedermann, D.; Ulrichova, J.; Vostalova, J., Phototoxic potential of silymarin and its bioactive components. Journal of Photochemistry and Photobiology B-Biology 2016, 156, 61-68. IF2016: 2.67
  9. Roubalová, L.; Biedermann, D.; Papoušková, B.; Vacek, J.; Kuzma, M.; Křen, V.; Ulrichová, J.; Dinkova-Kostova, A. T.; Vrba, J., Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264. 7 and Hepa1c1c7 cells. Chemico-Biological Interactions 2016, 260, 58-66. IF2016: 3.14
  10. Pyszkova, M.; Biler, M.; Biedermann, D.; Valentova, K.; Kuzma, M.; Vrba, J.; Ulrichova, J.; Sokolova, R.; Mojovic, M.; Popovic-Bijelic, A.; Kubala, M.; Trouillas, P.; Kren, V.; Vacek, J., Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. Free Radical Biology and Medicine 2016, 90, 114-125. IF2016: 5.61
  11. Kubala, M.; Cechova, P.; Geleticova, J.; Biler, M.; Stenclova, T.; Trouillas, P.; Biedermann, D., Flavonolignans As a Novel Class of Sodium Pump Inhibitors. Frontiers in Physiology 2016, 7. IF2016: 4.13
  12. Karas, D.; Gazak, R.; Valentova, K.; Chambers, C. S.; Pivodova, V.; Biedermann, D.; Krenkova, A.; Oborna, I.; Kuzma, M.; Cvacka, J.; Ulrichova, J.; Kren, V., Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells. Journal of Natural Products 2016, 79 (4), 812-820. IF2016: 3.28
  13. Huang, G.; Schramm, S.; Heilmann, J.; Biedermann, D.; Kren, V.; Decker, M., Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins. Beilstein Journal of Organic Chemistry 2016, 12, 662-669. IF2016: 2.34
  14. Biler, M.; Trouillas, P.; Biedermann, D.; Křen, V.; Kubala, M., Tunable optical properties of silymarin flavonolignans. Photochem. Photobiol. A-Chem. 2016, 328, 154-162. IF2013: 2.63
  15. Biedermann, D.; Buchta, M.; Holečková, V.; Sedlák, D.; Valentová, K.; Cvačka, J.; Bednárová, L.; Křenková, A.; Kuzma, M.; Škuta, C.; Peikerová, Ž.; Bartůněk, P.; Křen, V., Silychristin: Skeletal Alterations and Biological Activities. Journal of Natural Products 2016, 79 (12), 3086 – 3092. IF2016: 3.28
  16. Biler, M.; Biedermann, D.; Valentova, K.; Kren, V.; Kubala, M., Quercetin and its analogues: optical and acido-basic properties. Physical Chemistry Chemical Physics 2017, 19 (39), 26870-26879. IF2017: 3.91
  17. Filippopoulou, K.; Papaevgeniou, N.; Lefaki, M.; Paraskevopoulou, A.; Biedermann, D.; Křen, V.; Chondrogianni, N., 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound. Free Radical Biology and Medicine 2017, 103, 256-267. IF2017: 6.02
  18. Chambers, C. S.; Holeckova, V.; Petraskova, L.; Biedermann, D.; Valentova, K.; Buchta, M.; Kren, V., The silymarin composition … and why does it matter??? Food Research International 2017, 100, 339-353. IF2017: 3.52
  19. Roubalova, L.; Dinkova-Kostova, A. T.; Biedermann, D.; Kren, V.; Ulrichova, J.; Vrba, J., Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells. Fitoterapia 2017, 119, 13115-120. IF2017: 2.64
  20. Sokolova, R.; Kocabova, J.; Marhol, P.; Fiedler, J.; Biedermann, D.; Vacek, J.; Kren, V., Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral Study. Journal of Physical Chemistry B 2017, 121 (28), 6841-6846. IF2017: 3.15
  21. Vrba, J.; Papouskova, B.; Roubalova, L.; Zatloukalova, M.; Biedermann, D.; Kren, V.; Valentova, K.; Ulrichova, J.; Vacek, J. Metabolism of flavonolignans in human hepatocytes. Journal of Pharmaceutical and Biomedical Analysis 2018, 152, 94-101, 10.1016/j.jpba.2018.01.048. IF2018: 2.98
  22. Valentova, K.; Purchartova, K.; Rydlova, L.; Roubalova, L.; Biedermann, D.; Petraskova, L.; Krenkova, A.; Pelantova, H.; Holeckova-Moravcova, V.; Tesarova, E.; Cvacka, J.; Vrba, J.; Ulrichova, J.; Kren, V. Sulfated metabolites of flavonolignans and 2,3-dehydroflavonolignans: Preparation and properties. International journal of molecular sciences 2018, 19, 2349, 10.3390/ijms19082349. IF2018: 4.18
  23. Tvrdý, V.; Catapano, M.C.; Rawlik, T.; Karličková, J.; Biedermann, D.; Křen, V.; Mladěnka, P.; Valentová, K. Interaction of isolated silymarin flavonolignans with iron and copper. Journal of Inorganic Biochemistry 2018, 189, 115-123, 0.1016/j.jinorgbio.2018.09.006. IF2018: 3.22
  24. Sheehan, A.; Messer, A.E.; Papadaki, M.; Choudhry, A.; Kren, V.; Biedermann, D.; Blagg, B.; Khandelwal, A.; Marston, S.B. Molecular defects in cardiac myofilament ca2+-regulation due to cardiomyopathy-linked mutations can be reversed by small molecules binding to troponin. Frontiers in Physiology 2018, 9, 243, 10.3389/fphys.2018.00243. IF2018: 3.20
  25. Olías-Molero, A.; Jiménez-Antón, M.; Biedermann, D.; Corral, M.; Alunda, J. In-vitro activity of silybin and related flavonolignans against leishmania infantum and l. Donovani. Molecules 2018, 23, 1560, 10.3390/molecules23071560. IF2018: 3.06
  26. Hrčková, G.; Kubašková, T.M.; Benada, O.; Kofroňová, O.; Tumová, L.; Biedermann, D. Differential effects of the flavonolignans silybin, silychristin and 2,3-dehydrosilybin on mesocestoides vogae larvae (cestoda) under hypoxic and aerobic in vitro conditions. Molecules 2018, 23, 2999, 10.3390/molecules23112999. IF2018: 3.06
  27. Juráňová Jana, Aury-Landas Juliette, Boumediene Karim, Baugé Catherine, Biedermann David, Ulrichová Jitka, Franková Jana: Modulation of Skin Inflammatory Response by Active Components of Silymarin. Molecules, 24 (1), 123 (1-18) (2019). 18-00132S. IF 3,060 (3,380).
  28. Kosina Pavel, Paloncýová Markéta, Rajnochová Svobodová Alena, Zálešák Bohumil, Biedermann David, Ulrichová Jitka, Vostálová Jitka: Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study. Molecules, 24 (1), 61 (1-20) (2019). 15-10897S, P208/12/G016. IF 3,060 (3,380).
  29. Šuk Jakub, Jašprová Jana, Biedermann David, Petrásková Lucie, Valentová Kateřina, Křen Vladimír, Muchová Lucie, Vítek Libor: Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice. Oxidative Medicine and Cellular Longevity, Volume 2019, Article ID 6026902, 1-12 (2019). 16-27317A. IF 4,868 (5,392).
  30. Biedermann David, Moravcová Veronika, Valentová Kateřina, Kuzma Marek, Petrásková Lucie, Císařová Ivana, Křen Vladimír: Oxidation of flavonolignan silydianin to unexpected lactone-acid derivative. Phytochemistry Letters, 30, 14-20 (2019). 18-00150S, LTC18071, LTC17009, LTC18003. IF 1,338 (1,506).
  31. Vostálová Jitka, Tinková Eva, Biedermann David, Kosina Pavel, Ulrichová Jitka, Rajnochová Svobodová Alena: Skin Protective Activity of Silymarin and its Flavonolignans. Molecules, 24 (6), 1022 (1-12) (2019). LTC18071. IF 3,060 (3,380).
  32. Valentová Kateřina, Biedermann David, Křen Vladimír: 2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases. Proceedings, 11 (1), 21:1-4 (2019). 18-00132S.
  33. Begines Paloma, Biedermann David, Valentová Kateřina, Petrásková Lucie, Pelantová Helena, Maya Inés, Fernández-Bolaños G. José, Křen Vladimír: Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol, Tyrosol, and Acetylated Derivatives. Journal of Agricultural and Food Chemistry, 67 (26), 7281-7288 (2019). 18-00121S, 19-00043S. IF 3,571 (3,911).
  34. Chambers S. Christopher, Biedermann David, Valentová Kateřina, Petrásková Lucie, Viktorová Jitka, Kuzma Marek, Křen Vladimír: Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties. Antioxidants, 8 (7), 236:1-12 (2019). LTC17009. IF 4,520 (n/a).
  35. Viktorová Jitka, Dobiasová Simona, Řehořová Kateřina, Biedermann David, Káňová Kristýna, Šeborová Karolína, Václavíková Radka, Valentová Kateřina, Ruml Tomáš, Křen Vladimír, Macek Tomáš: Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Avtivity of Silychristin Derivatives. Antioxidants, 8 (8), 303:1-19 (2019). 18-00150S, LTC19007, LTC19020. IF 4,520 (n/a).
  36. Rajnochová Svobodová Alena, Gabrielová Eva, Ulrichová Jitka, Zálešák Bohumil, Biedermann David, Vostálová Jitka: A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts. Archives of Dermatological Research, 311 (6), 477-490 (2019). IF 2,309 (2,486).
  37. Pourová Jana, Applová Lenka, Macáková Kateřina, Vopršalová Marie, Migkos Thomas, Bentanachs Roger, Biedermann David, Petrásková Lucie, Tvrdý Václav, Hrubša Marcel, Karlíčková Jana, Křen Vladimír, Valentová Kateřina, Mladěnka Přemysl: The Effect of Silymarin Flavonolignans and Their Sulfated Conjugates on Platelet Aggregation and Blood Vessels Ex Vivo. Nutrients, 11 (10), 2286: 1-16 (2019). 18-00121S, LTC18003, LTC18071. IF 4,171 (4,813).
  38. Petrásková Lucie, Káňová Kristýna, Biedermann David, Křen Vladimír, Valentová Kateřina: Simple and Rapid HPLC Separation and Quantification of Flavonoid, Flavonolignans, and 2,3-Dehydroflavonolignans in Silymarin. Foods, 9 (2), 116:1-14 (2020). 18-00132S, LTC18003, 19039. IF 3,011 (n/a).
  39. Chambers S. Christopher, Viktorová Jitka, Řehořová Kateřina, Biedermann David, Turková Lucie, Macek Tomáš, Křen Vladimír, Valentová Kateřina: Defying Multidrug Resistance! Modulation of related Transporters by Flavonoids and Flavonolignans. Journal of Agricultural and Food Chemistry, 68 (7), 1763-1779 (2020). 18-00150S. IF 3,571 (3,911).
  40. Martinkova, L., Prihodova, R.; Kulik, N.; Pelantova, H.; Kristkova, B.; Petraskova, L.; Biedermann, D. Biocatalyzed reactions towards functional food components 4-alkylcatechols and their analogues. Catalysts 2020, 10, doi:10.3390/catal10091077.
  41. Hurtova, M.; Biedermann, D.; Kuzma, M.; Kren, V. Mild and selective method of bromination of flavonoids. Journal of Natural Products 2020, 83, 3324-3331, doi:10.1021/acs.jnatprod.0c00655.
  42. Hrckova, G.; Kubaskova, T.M.; Reiterova, K.; Biedermann, D. Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, th1/th2/tregs cytokines and down-regulation of fibrogenesis in mice with mesocestoides vogae (cestoda) infection. Experimental Parasitology 2020, 213, doi:10.1016/j.exppara.2020.107888.
  43. Dobiasova, S.; Rehorova, K.; Kucerova, D.; Biedermann, D.; Kanova, K.; Petraskova, L.; Koucka, K.; Vaclavikova, R.; Valentova, K.; Ruml, T.; et al. Multidrug resistance modulation activity of silybin derivatives and their anti-inflammatory potential. Antioxidants 2020, 9, doi:10.3390/antiox9050455.
  44. Lomozova, Z.; Tvrdy, V.; Hrubsa, M.; Catapano, M.C.; Macakova, K.; Biedermann, D.; Kucera, R.; Kren, V.; Mladenka, P.; Valentova, K. Dehydroflavonolignans from silymarin potentiate transition metal toxicity in vitro but are protective for isolated erythrocytes ex vivo. Antioxidants 2021, 10, doi:10.3390/antiox10050679.
  45. Frankova, J.; Juranova, J.; Biedermann, D.; Ulrichova, J. Influence of silymarin components on keratinocytes and 3d reconstructed epidermis. Toxicology in Vitro 2021, 74, doi:10.1016/j.tiv.2021.105162.
  46. Biedermann, D.; Hurtova, M.; Biedermannova, L.; Valentova, K.; Kren, V. Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper j. Mol. Recognit. E2812 (2019). Journal of Molecular Recognition 2021, 34, doi:10.1002/jmr.2888.

 

 

Last update: February 22, 2022