TRAINING SCHOOL: ”ADVANCED TRAINING IN SYNTHESIS AND APPLICATIONS OF MULTIVALENT GLYCONANOMATERIALS”
Conference Chair: Vladimír Křen
Conference Secretary: Pavla Bojarová
Tuesday 29th March | |
---|---|
COST TRAINING SCHOOL (Institute of Molecular Genetics, building F) | |
08.30 – 09.00 | Registration |
09.00 – 09.20 | Welcome – M.C. Galan, B.W. Turnbull, V. Křen |
09.20 – 11.00 | SynBIOcarb ESR Individual Presentations, Chair: Dajana Kolanović |
09.20 – 09.40 | O-01 Laia Saltor Núñez (Leeds, UK) – Derivatization of hyaluronan for mucin-like structures in glycocalyx models (P-2) |
09.40 – 10.00 | O-02 Chunyue (Spring) Wang (Leeds, UK) – Superselective targeting of tumour cells |
10.00 – 10.20 | O-03 Lina Siukstaite (Freiburg, DE) – The two sweet sides of janus lectin drive crosslinking of liposomes to cancer cells and material uptake |
10.20 – 10.40 | O-04 Francesca Rosato (Freiburg, DE) – A clickable lectibody activates CD8+ cytotoxic T cells and induces cancer cell death (P-4) |
10.40 – 11.00 | O-05 Simona Notova (Grenoble, FR) – Punching holes in cancer cells: A pore-forming ß-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3 (P-7) |
11.00 – 11.30 | Coffee Break, poster installation (registration) |
11.30 – 13.15 | SynBIOcarb ESR Individual Presentations, Chair: Rajeev Pasupuleti |
11.30 – 11.50 | O-06 Dylan Jabeguero (Grenoble, FR) – Expansion of synthetic glycobiology tools: Altering the donor specificity of a glycosyltransferase (P-5) |
11.50 – 12.10 | O-07 Dajana Kolanović (Vienna, AT) – Directed surface immobilization of single-chain galectin-1 improves its ligand binding (P-16) |
12.10 – 12.30 | O-08 Rajeev Pasupuleti (Vienna, AT) – Lectin-antibody Stx1B-OKT3 induces T cell triggered immune response against CD77+ tumor cells (P-18) |
12.30 – 12.50 | O-09 Juvissan Aguedo (Bratislava, SK) – Application of MXenes for high enrichment of N-glycans and differentiation of sialic acid linkages (P-15) |
12.50 – 13.10 | O-10 Paras Kundalia (Bratislava, SK) – Lectin-based glycoprotein microarray: crucial parameters and application in cancer patients’ sera glycoprofiling (P-17) |
13.15 – 14.30 | Lunch |
14.30 – 15.30 | Hot Topics in glycobiology (tutorials), Chair: M. Carmen Galan |
14.30 – 14.50 | T-01 Hot Topic 1: Birte Svensson (Kgs. Lyngby, DK) – Rational enzyme design without structural knowledge: a sequence-based approach for efficient generation of tranglycosylases Virtual |
14.50 – 15.10 | T-02 Hot Topic 2: Rob Young (Blue Burgundy Ltd., UK) – Some physical aspects of carbohydrate drug binding |
15.10 – 15.30 | T-03 Hot Topic 3: Rob Field (Manchester, UK) – Sequence, structure, function in glycospace |
15.30 – 18.00 | Coffee Break, posters |
16.00 – 17.00 | External Advisory Board (EAB) ESR Tutorials |
17.00 – 18.00 | Poster Session |
18.00 – 21.00 | Conference Dinner – get together (Institute of Molecular Genetics, building F) |
Wednesday 30th March | |
COST TRAINING SCHOOL (Institute of Microbiology, building A) | |
09.00 – 9.30 | Registration (Institute of Microbiology, building A) |
09.30 – 11.10 | SynBIOcarb ESR Individual Presentation, Chair: Bruce Turnbull |
09.30 – 09.50 | O-11 Federica Vena (L’Orleans, FR) – Lectin array for quality control of recombinant biotherapeutic glycoproteins |
09.50 – 10.10 | O-12 Natalia Danielewicz (Vienna, AT) – Process development for high yield fermentation of active recombinant lectins expressed in Escherichia coli (P-6) |
10.10 – 10.30 | O-13 Wenyue (Eva) Dai (Leeds, UK) – Assemble multiple CTB5 by coiled coil for GUV fusion Virtual |
10.30 – 10.50 | O-14 Spyridon Gatos (Lungby, DK) – Novel strategies and technologies for the development of tumor therapeutic antibodies (P-22) Virtual |
10.50 – 11.10 | O-15 Ilaria Mainero Rocca (Lungby, DK) – Glycoengineered Microbiome-based anti- infectives and novel-glycomic display systems (P-21) Virtual |
11.10 – 12.10 | Coffee Break, posters (Institute of Molecular Genetics, building F) |
12.10 – 13.30 | Hot Topics in multivalent glyconanomaterials, Chair: Viktoria Heine (Institute of Microbiology, building A) |
12.10 – 12.30 | T-04 Paul V. Murphy (Galway, IE) – Protecting group chemistry for synthetic glycoscience (tutorial) |
12.30 – 12.50 | T-05 Trinidad Velasco-Torrijos (Maynooth, IE) – Conjugation approaches for glycomaterials (tutorial) |
12.50 – 13.10 | O-16 K.F. Warfel (Evantston, US) – Cell-free protein synthesis: applications in synthetic glycobiology |
13.10 – 13.30 | O-17 Ralf Richter (Leeds, UK) – A novel sliding interaction between the extracellular matrix polysaccharide hyaluronan and the lymphatic vessel endothelial receptor LYVE-1 that regulates immune cell trafficking |
13.30 – 14.30 | Lunch (Institute of Molecular Genetics, building F) |
14.30 – 15.30 | COST TRAINING SCHOOL, Chair: Paul V. Murphy (Institute of Microbiology, building A) |
14.30 – 14.50 | T-06 M. Carmen Galan (Bristol, UK) – Novel multivalent synthetic platforms as potential theranostics (tutorial) |
14.50 – 15.10 | O-18 Manuel Gonzalez-Cuesta (Seville, ES) – sp2 – Iminosugar glycomimetics for OGA profiling |
15.10 – 15.30 | O-19 Carina Dey (Aachen, DE) – Characterization of galectin fusion proteins with glycoprotein affinity columns and binding assays |
15.30 – 16.30 | Coffee Break, posters (Institute of Molecular Genetics, building F) |
16.30 – 18.00 | COST TRAINING SCHOOL, Chair: Trinidad Velasco-Torrijos (Institute of Microbiology, building A) |
16.30 – 16.50 | T-07 Miluše Vlachová (Prague, CZ) – Biological methods of assessment of galectin-glyconanomaterial interactions (tutorial) |
16.50 – 17.10 | O-20 Francesco Milanesi (Florence, IT) – Synthetic receptors for carbohydrates: an effective tool to interfere in carbohydrates recognition |
17.10 – 17.30 | O-21 Michaela Hovorková (Prague, CZ) – Preparation of high-affinity galectin ligands and their multivalent effect |
17.30 – 17.50 | O-22 Irene Herrera González (Seville, ES) – Synthesis of sp2-iminosugar-based mannobioside glycomimetics ligands targeting c-type lectin receptors (P-10) |
Free evening | |
Thursday 31th March | |
COST TRAINING SCHOOL & Workshop (Institute of Molecular Genetics, building F) | |
09.00 – 9.30 | Registration |
09.30 – 10.40 | COST TRAINING SCHOOL & Workshop sessions, Chair: Priyanka Sahariah |
09.30 – 10.00 | T-08 Pavla Bojarová (Prague, CZ) – Targeting galectins with high-affinity glycoconjugates – successes, challenges, and bottlenecks (tutorial) |
10.00 – 10.20 | O-23 Marcela Šišić (Zagreb, HR) – Functional glyconanomaterials based on bacterial peptidoglycan for targeted drug delivery and surface recognition studies |
10.20 – 10.40 | O-29 Simon Johnson (Bristol, UK) – Synthesis of multivalent mucin-type O-glycan analogues for use as diagnostic probe |
10.40 – 11.10 | Coffee Break, posters |
11.10 – 13.00 | COST TRAINING SCHOOL & Workshop sessions, Chair: Zdeněk Wimmer |
11.10 – 11.30 | O-25 David Vrbata (Prague, CZ) – Multivalent glycomimetics as inhibitors of galectin-3 |
11.30 – 11.50 | O-26 Adamantia Apostolopoulou (Athens, GR) – In vivo tracking of radiolabeled nanostructures |
11.50 – 12.10 | O-27 Maria Psarrou (Crete, GR) – Polysaccharide-functionalized iron oxide nanoparticles for mRNA delivery |
12.10 – 12.30 | O-28 Joana Gonçalves (Aveiro, PT) – Development of magnetic composites for magnetic hyperthermia therapy and bone regeneration |
12.30 | Conference dinner information |
12.30 – 14.00 | Lunch (posters to be removed) |
14.00 – 17.00 | Networking COST Working group 1 |
18.00 – 21.00 | Conference Dinner |
Friday 1st April | |
COST Workshop (Institute of Microbiology, building A) |
|
09.00 – 09.30 | Registration |
09.30 – 12.00 | COST sessions, Chair: Kateřina Valentová |
09.30 – 09.50 | T-09 Priyanka Sahariah (Reykjavik, IS) – Chitosan peptide conjugates against bacterial biofilms (tutorial) |
09.50 – 10.10 | T-10 Vladimír Křen (Prague, CZ) – Enzymatic synthesis of glycoconjugates with glycosidases: Diglycosidase rutinosidase (tutorial) |
10.10 – 10.30 | O-30 Viktoria Heine (Prague, CZ) – Poly-LacNAc-decorated neo-glycoproteins and their interaction with tandem-repeat galectins |
10.30 – 10.50 | O-31 Ana Barra (Aveiro, PT) – Development of biopolymer-based electrically conductive biocomposites |
10.50 – 11.10 | O-33 Jack Schofield (Galway, IE) – Fucosylation inhibition ameliorates inflammatory glycosylation & metabolism in corneal fibroblasts (P-20) |
11.10 – 11.30 | free slot |
11.30 – 12.00 | Coffee Break, packed lunch boxes and departure for travel |
List of Posters
- Siukstaite (Freiburg, D): The two sweet sides of janus lectin drive crosslinking of liposomes to cancer cells and material uptake (O-3)
- (Spring) Wang & L.S. Núñez (Leeds, UK): Derivatization of hyaluronan and their applications (O-1)
- F. Warfel (Evantston, US) A low-cost, thermostable, cell-free protein synthesis platform for on-demand production of glycoconjugate vaccines
- Rosato (Freiburg, D) A clickable lectibody activates CD8+ cytotoxic T cells and induces cancer cell death (O-4)
- Jabeguero (Grenoble, F) Expansion of synthetic glycobiology tools: Altering the donor specificity of a glycosyltransferase (O-6)
- Danielewicz (Vienna, A) Process development for high yield fermentation of active recombinant lectins expressed in Escherichia coli (O-12)
- Notova (Grenoble, F) Janus lectins and neo-lectins: engineering of new scaffolds and topology (O-5)
- M. Saladino (Stockholm, S) Single step synthesis of sugar ligand coated superparamagnetic iron oxide nanoparticles with antibacterial properties
- Fitzgerald (Gatway, IE) Outcome of docking of some simple sialic acid derivatives to influenza hemagglutinin and synthesis of glycoclusters based on tetraphenylethylene scaffold
- Herrera González (Seville, E) Synthesis of sp2-iminosugar-based mannobioside glycomimetics ligands targeting c-type lectin receptors (O-22)
- Meszáros (Prague, CZ) Mutant hypertransglycosylating GH20 β-N-hexosaminidases for the synthesis of bioactive chitooligomers
- Brodsky (Prague, CZ) Rutinosidase and its application in the synthesis of glycoconjugates
- Červený (Prague, CZ) Biolayer interferometry – a great tool for decoding the kinetic of lectin-carbohydrate interaction
- Konvalinková (Prague, CZ) Glycocalix[4]arenes and their affinity to a galectin library
- Aguedo & F. Vena (Bratislava, SK; Orleans, FR) Rapid and high throughput methods for discrimination of sialic acids linkages in glycoproteins
- Kolanović (Graz, AT) Directed surface immobilization of single-chain galectin-1 improves its ligand binding (O-7)
- Kundalia (Bratislava, SK) Lectin-based glycoprotein microarray: crucial parameters and application in cancer patients’ sera glycoprofiling (O-10)
- Pasupuleti (Vienna, AT) Lectin-antibody Stx1B-OKT3 induces T cell triggered immune response against CD77+ tumor cells (O-8)
- Wenyue Dai (Leeds, UK) Exploring structure-activity relationships of defined streptavidin-bacterial toxin assemblies that induce membrane crosslinking and fusion
- Schofield (Galway, IE) Fucosylation inhibition ameliorates inflammatory glycosylation & metabolism in corneal fibroblasts (O-33)
- Rocca (Lyngby, DK) Glycoengineered Microbiome-based anti-infectives and novel-glycomic display systems (O-15)
- Gatos (Lyngby, DK) Novel strategies and technologies for the development of tumor therapeutic antibodies
- Illenseer Katharina (Konstanz, DE) Synthesis of multivalent AB5 toxin inhibitors