2024 Publications

  • Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation

Tímea Bencsik, Orsolya Balázs, Róbert G. Vida, Balázs Z. Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór

Journal of the Science of Food and Agriculture, online 14045:1-12     PDF 

  • Nutraceuticals Silybin B, resveratrol, and epigallocatechin-3 gallate (EGCG) bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

Yang Zeyu, Sheehan Alice M., Messer Andrew E., Tsui Sharmane, Sparrow Alexander, Redwood Charles, Křen Vladimír, Gould Ian R., Marston Steven B.

Frontiers in Physiology, 15, 1489439:1-15     PDF

  • Aldoxime dehydratases: production, immobilization, and use in multistep processes

Ludmila Martínková, Michael Kotík, Natalia Kulik, Barbora Křístková, Katarína Šťastná, Margit Winkler

Applied Microbiology and Biotechnology, 108, 1, 518: 1-19     PDF

  • Mutual Interactions of Silymarin and Colon Microbiota in Healthy Young and Healthy Elder Subjects

Tomisová Kateřina, Jarošová Veronika, Maršík Petr, Bergo Mascellani Anna, Cinek Ondřej, Hlináková Lucie, Klouček Pavel, Janoušek Václav, Valentová Kateřina, Havlík Jaroslav

Molecular Nutrition & Food Research, 68, 22, 2400500: (1-14)     PDF

  • The variable structural flexibility of the Bacillus circulans β-galactosidase isoforms determines their unique functionalities

Michaela Hovorková, Barbora Kaščáková, Lucie Petrásková, Petra Havlíčková, Jiří Nováček, Daniel Pinkas, Zdenko Gardian, Vladimír Křen, Pavla Bojarová, Ivana Kutá Smatanová

Structure, 32, 1-15     PDF 

  • New Bacterial Aryl Sulfotransferases: Effective Tools for Sulfation of Polyphenols

Katerina Brodsky, Barbora Petránková, Lucie Petrásková, Helena Pelantová, Vladimír Křen, Kateřina Valentová, Pavla Bojarová

Journal of Agricultural and Food Chemistry, 72, 40, 22208-22216     PDF

  • Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion-transporting polypeptides (OATP1B1 and OATP2B1)

Ágnes Dombi, Hana Kaci, Kateřina Valentová, Éva Bakos, Csilla Özvegy-Laczka, Miklós Poór

Pharmacology Research & Perspectives, 12, 5, e70021: 1-12     PDF

  • Nitrogen-Containing Flavonoids–Preparation and Biological Activity

Martina Hurtová, Daniela Brdová, Bára Křížskovská, Guglielmo Tedeschi, Tomáš Nejedlý, Ondřej Strnad, Simona Dobiasová, Zuzana Osifová, Gabriela Kroneislová, Jan Lipov, Kateřina Valentová, Jitka Viktorová, Vladimír Křen

ACS Omega, 9, 32, 34938-34950     PDF

  • Three-Step Enzymatic Remodeling of Chitin into Bioactive Chitooligomers

Zuzana Mészáros, Natalia Kulik, Lucie Petrásková, Pavla Bojarová, Mònica Texidó, Antoni Planas, Vladimír Křen, Kristýna Slámová

Journal of Agricultural and Food Chemistry, 72, 28, 15613-15623     PDF

  • Glycopolymer Inhibitors of Galectin-3 Suppress the Markers of Tissue Remodeling in Pulmonary Hypertension

Antonín Sedlář, David Vrbata, Kateřina Pokorná, Kristýna Holzerová, Jakub Červený, Olga Kočková, Markéta Hlaváčková, Martina Doubková, Jana Musílková, Vladimír Křen, František Kolář, Lucie Bačáková, Pavla Bojarová

Journal of Medicinal Chemistry, 67, 11, 9214-9226     PDF

  • Expanding Rutinosidase Versatility: Acylated Quercetin Glucopyranosides as Substrates

Katerina Brodsky, Lucie Petrásková, Michal Kutý, Pavla Bojarová, Helena Pelantová, Vladimír Křen

ChemCatChem, 16, 11, e202400028: 1-7     PDF

  • Biotransformation of free cyanide to formic acid by a cyanide hydratase-formamidase cascade reaction

Ludmila Martínková, Natalia Kulik, Lenka Rucká, Michael Kotík, Barbora Křístková, Katarína Šťastná, Petr Novotný, Romana Příhodová, Pavla Bojarová, Miroslav Pátek

Process Biochemistry, 142, July 2024, 62-67     PDF

  • Diaminocyclopentane – L-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase

Patrick Weber, Pavla Bojarová, Jitka Brouzdová, Vladimír Křen, Natalia Kulik, Arnold E. Stütz, Martin Thonhofer, Tanja M. Wrodnigg

Bioorganic Chemistry, 148, July 2024, 107452: 1-12     PDF

  • Synthesis and unexpected binding of monofluorinated N, N‘-diacetylchitobiose and LacdiNAc to wheat germ agglutinin

Martin Kurfiřt, Vojtěch Hamala, Jan Beránek, Lucie Červenková Šťastná, Jakub Červený, Martin Dračínský, Jana Bernášková, Vojtěch Spiwok, Zuzana Bosáková, Pavla Bojarová, Jindřich Karban

Bioorganic Chemistry, 147, June 2024, 107395: 1-12     PDF

  • The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1 and OATP2B1

Hana Kaci, Éva Bakos, Paul W. Needs, Paul A. Kroon, Kateřina Valentová, Miklós Poór, Csilla Özvegy-Laczka

European Journal of Pharmaceutical Sciences, 196, 1 May 2024, 106740: 1-10     PDF

  • Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation

Z. Dostál, A.V. Zholobenko, H. Přichystalová, B. Gottschalk, K. Valentová, R. Malli, M. Modrianský

Biochemical Pharmacology, 222, April 2024, 116094: 1-12     PDF

  • Immobilization of aldoxime dehydratases on metal affinity resins and use of the immobilized catalysts for the synthesis of nitriles important in fragrance industry

Barbora Křístková, Ludmila Martínková, Lenka Rucká, Michael Kotík, Natalia Kulik, Robert Rädish, Margit Winkler, Miroslav Pátek

Journal of Biotechnology, 384, 20 March 2024, 12-19     PDF

  • Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient

David Vrbata, Jakub Červený, Natalia Kulik, Michaela Hovorková, Soňa Balogová, Miluše Vlachová, Helena Pelantová, Vladimír Křen, Pavla Bojarová

Bioorganic Chemistry, 145, April 2024, 107231: 1-13     PDF

  • Cell-free reduction of carboxylic acids with secreted carboxylic acid reductase

Dominic Goj, Stella Ebner, Melissa Horvat, Simon Arhar, Ludmila Martínková, Margit Winkler

Journal of Biotechnology, 382, February 2024, 44-50     PDF

  • Multimodal Carbon Monoxide Photorelease from Flavonoids

Andrea Ramundo, Martina Hurtová, Igor Božek, Zuzana Osifová, Marina Russo, Bokolombe Pitchou Ngoy, Vladimír Křen, Petr Klán

Organic Letters, 26, 3, 708-712     PDF