2020 Publications (25)

  • Mild and Selective Method of Bromination of Flavonoids

Martina Hurtová, David Biedermann, Marek Kuzma, Vladimír Křen

Journal of Natural Products, 83, 11, 3324-3331     PDF

  • Sulfated Metabolites of Luteolin, Myricetin, and Ampelopsin: Chemoenzymatic Preparation and Biophysical Properties

Kristýna Káňová, Lucie Petrásková, Helena Pelantová, Zuzana Rybková, Kateřina Malachová, Josef Cvačka, Vladimír Křen, Kateřina Valentová

Journal of Agricultural and Food Chemistry, 68, 40, 11197-11206     PDF

  • How Site-Directed Mutagenesis Boosted Selectivity of a Promiscuous Enzyme

Pavlína Nekvasilová, Natalia Kulik, Nikola Rychlá, Helena Pelantová, Lucie Petrásková, Zuzana Bosáková, Josef Cvačka, Kristýna Slámová, Vladimír Křen, Pavla Bojarová

Advanced Synthesis & Catalysis, 362, 19, 4138-4150     PDF     

  • Biocatalyzed Reactions towards Functional Food Components 4-Alkylcatechols and Their Analogues

Ludmila Martínková, Romana Příhodová, Natalia Kulik, Helena Pelantová, Barbora Křístková, Lucie Petrásková, David Biedermann

Catalysts, 10, 9, 1077, 1-14     PDF

  • Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD+ Ratio

Lydie Plecitá-Hlavatá, Hana Engstová, Blanka Holendová, Jan Tauber, Tomáš Špaček, Lucie Petrásková, Vladimír Křen, Jitka Špačková, Klára Gotvaldová, Jan Ježek, Andrea Dlasková, Katarína Smolková, Petr Ježek

ANTIOXIDANTS & REDOX SIGNALING, 33, 12, 789-815     PDF

  • Plant Nitrilase Homologues in Fungi: Phylogenetic and Functional Analysis with Focus on Nitrilases in Trametes versicolor and Agaricus bisporus

Lenka Rucká,  Natalia Kulik, Petr Novotný, Anastasia Sedova, Lucie Petrásková, Romana Příhodová, Barbora Křístková, Petr Halada, Miroslav Pátek, Ludmila Martínková

Molecules, 25, 17, 3861, 1-20     PDF

  • Regioselective 3-O-Substitution of Unprotected Thiodigalactosides: Direct Route to Galectin Inhibitors

     Tomáš Vašíček, Vojtěch Spiwok, Jakub Červený, Lucie Petrásková, Ladislav Bumba, David Vrbata, Helena Pelantová, Vladimír Křen, Pavla Bojarová

Chemistry-A European Journal 26, 43, 9620-9631     PDF

  • Glycopolymers for Efficient Inhibition of Galectin-3: In Vitro Proof of Efficacy Using Suppression of T Lymphocyte Apoptosis and Tumor Cell Migration

Marcela Filipová, Pavla Bojarová, Marina Rodrigues Tavares, Ladislav Bumba, Lothar Elling, Petr Chytil, Kristýna Gunár, Vladimír Křen, Tomáš Etrych, Olga Janoušková

Biomacromolecules, 21, 8, 3122-3133     PDF

  • Cytoprotective Activity of Natural and Synthetic Antioxidants

Kateřina Valentová

Antioxidants, 9, 8, 713, 1-4     PDF

  • Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin

Jiří Vrba, Barbora Papoušková, Pavel Kosina, Kateřina Lněničková, Kateřina Valentová, Jitka Ulrichová

Metabolites, 10, 8, 329, 1-13     PDF

  • Biocatalysis: “A Jack of all Trades…”

Vladimír Křen, Pavla Bojarová

International Journal of Molecular Sciences, 21, 14, 5115, 1-3     PDF

  • Dual Substrate Specificity of the Rutinosidase  from Aspergillus niger and the Role of Its Substrate Tunnel

Katerina Brodsky, Michal Kutý, Helena Pelantová, Josef Cvačka, Martin Rebroš, Michael Kotík, Ivana Kutá Smatanová, Vladimír Křen, Pavla Bojarová

International Journal of Molecular Sciences, 21, 16, 5671, 1-21     PDF

  • Rutinosidase from Aspergillus niger: crystal structure and insight into the enzymatic activity

Petr Pachl, Jana Kapešová, Jiří Brynda, Lada Biedermannová, Helena Pelantová, Pavla Bojarová, Vladimír Křen, Pavlína Řezáčová, Michael Kotík

The FEBS Journal, 287, 15, 3315-3327     PDF

  • Transglycosidase activity of glycosynthase-type mutants of a fungal GH20 β-N-acetylhexosaminidase

Jana Kapešová, Lucie Petrásková, Natalia Kulik, Zuzana Straková, Pavla Bojarová, Kristína Markošová, Martin Rebroš, Vladimír Křen, Kristýna Slámová

International Journal of Biological Macromolecules, 161, 1206-1215     PDF

  • Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti‐inflammatory Potential

Simona Dobiasová, Kateřina Řehořová, Denisa Kučerová, David Biedermann, Kristýna Káňová, Lucie Petrásková, Kamila Koucká, Radka Václavíková, Kateřina Valentová, Tomáš Ruml, Tomáš Macek, Vladimír Křen, Jitka Viktorová

Antioxidants, 2020,  9 (5), 455, 1-25     PDF

  • Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum

Antonia Diukendjieva, Maya M. Zaharieva, Mattia Mori, Petko Alov, Ivanka Tsakovska, Tania    Pencheva, Hristo Najdenski, Vladimír Křen, Chiara Felici, Francesca Bufalieri,  Lucia Di Marcotullio, Bruno  Botta, Maurizio Botta, Ilza Pajeva

         Antioxidants, 2020, 9 (5), 384, 1-12     PDF

  • Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection

          Gabriela Hrčková, Terézia Mačák Kubašková, Katarína Reiterová, Biedermann David

           Experimental Parasitology, 2020, 213, 107888, 1-11     PDF