Galectins are a family of animal proteins widely recognized for their involvement in a variety of biological processes, including cell-cell interactions, cell signaling, migration, adhesion, and the regulation of apoptosis. In humans, twelve galectins have been identified, with certain members such as Galectin-1 (Gal-1), Galectin-3 (Gal-3), Galectin-4 (Gal-4), Galectin-7 (Gal-7), Galectin-8 (Gal-8), and Galectin-9 (Gal-9) being extensively studied in our laboratory, especially in the context of cancer. These proteins play critical roles in tumor progression, metastasis, and immune modulation, making them significant targets for cancer research and therapy.
Figure 1 – Visualization of all of three structural motives
Literature
- Laaf Dominic, Bojarová Pavla, Elling Lothar, Křen Vladimír: Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology. Trends in Biotechnology, 37 (4), 402-415 (2019).
- Tomáš Vašíček, Vojtěch Spiwok, Jakub Červený, Lucie Petrásková, Ladislav Bumba, David Vrbata, Helena Pelantová, Vladimír Křen, Pavla Bojarová: Regioselective 3-O-Substitution of Unprotected Thiodigalactosides: Direct Route to Galectin Inhibitors. Chemistry-A European Journal, 26 (43), 9620-9631 (2020).
- Vrbata David, Filipová Marcela, Tavares R. Marina, Červený Jakub, Vlachová Miluše, Šírová Milada, Pelantová Helena, Petrásková Lucie, Bumba Ladislav, Konefal Rafal, Etrych Tomáš, Křen Vladimír, Chytil Petr, Bojarová Pavla: Glycopolymers Decorated with 3‑O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin‑3. Journal of Medicinal Chemistry, 65 (5), 3866-3878 (2022).
- Dorota Konvalinková, František Dolníček, Michaela Hovorková, Jakub Červený, Ondřej Kundrát, Helena Pelantová, Lucie Petrásková, Josef Cvačka, Margarita Faizulina, Beena Varghese, Petr Kovaříček, Vladimír Křen, Pavel Lhoták, Pavla Bojarová: Glycocalix[4]arenes and their affinity to a library of galectins: the linker matters. Organic & Biomolecular Chemistry, 21 (6), 1294-1302 (2023).
- Michaela Hovorková, Jakub Červený, Ladislav Bumba, Helena Pelantová, Josef Cvačka, Vladimír Křen, Olivier Renaudet, David Goyard, Pavla Bojarová: Advanced high-affinity glycoconjugate ligands of galectins. Bioorganic Chemistry, 131 (February 2023), 106279: 1-12 (2023).
- Kristýna Slámová, Jakub Červený, Zuzana Mészáros, Tereza Friede, David Vrbata, Vladimír Křen, Pavla Bojarová: Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly. Molecules, 28 (10), 4039: 1-15 (2023).
- Miluše Vlachová, Van Nguyen Tran, Jakub Červený, František Dolníček, Lucie Petrásková, Helena Pelantová, Ondřej Kundrát, Josef Cvačka, Zuzana Bosáková, Vladimír Křen, Pavel Lhoták, Jitka Viktorová, Pavla Bojarová: Galectin-targeting glycocalix[4]arenes can enter the cells†. Chemical Communications, 59, 10404-10407 (2023).
Cooperation
- Prof. J. Jiménez-Barbero, CIC bioGUNE, Derio, Bizkaia, Spain
- Assoc. prof. J. Viktorová, University of Chemistry and Technology, Prague, Czechia
- Dr. T. Etrych, Institute of Macromolecular Chemistry CAS, Prague, Czechia
- Prof. L. Elling, RWTH Aachen University, Aachen, Germany